Article Data

  • Views 1448
  • Dowloads 180

Original Research

Open Access

COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS 

  • Bo Ram Choi1,†
  • Jae Sung Pyo2,†
  • Mi Seon Yeo2
  • Min-Gul Kim3
  • Yu Seob Shin6
  • Yu Seob Shin1
  • Sung Won Lee4
  • Chul Young Kim5
  • Insuk So7
  • Hye Kyung Kim2
  • Jong Kwan Park6

1Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea

2College of Pharmacy and Brain Busan 21 program, Kyungsung University, Busan, Republic of Korea

3Department of Pharmacology, School of Medicine, Jeonbuk National University, Jeonju, Republic of Korea

4Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

5College of Pharmacy, Hanyang University, Ansan, Republic of Korea

6Department of Urology, Jeonbuk National University and Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Jeonbuk National University Hospital, Jeonju, Republic of Korea

7Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, South Korea

DOI: 10.15586/jomh.v16iSP1.235 Vol.16,Issue SP1,April 2020 pp.57-70

Published: 01 April 2020

*Corresponding Author(s): Hye Kyung Kim E-mail: fiona30@ks.ac.kr
*Corresponding Author(s): Jong Kwan Park E-mail: rain@jbnu.ac.kr

† These authors contributed equally.

Abstract

Background and Objective

This study has evaluated the pharmacokinetic parameters and bioavailabilities of monotropein, kae-mpferol-3-O-glucoside, and quercetin-4’-O-glucoside after administration of MOTILIPERM in rats.

Material and Methods

Following the administration of MOTILIPERM, the plasma concentrations of each compound in rats were simultaneously determined by using liquid chromatography tandem mass spectrometry (LC-MS/MS).

Results

The pharmacokinetic parameters of monotropein in rats were AUCinf 20,020.44±3944.67 and 11,915.53±1190.91 min·ng/mL and Cmax 286.99±38.37 and 56.23±9.02 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of kaempferol-3-O-glucoside in rats were AUCinf 287.86±126.17 min·ng/mL and not estimated; Cmax 5.80±1.87 and 1.24±0.41 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of querce-tin-4’-O-glucoside in rats were AUCinf 511.38±248.11 and 481.44±65.72 min·ng/mL; Cmax 10.72±2.70 and 2.83±0.34 ng/mL for intravenous and oral administration, respectively. 

Conclusion

The absolute bioavailabilities of monotropein and quercetin-4’-O-glucoside for oral administration were evaluated and calculated as 3.0 and 4.7%, respectively. The absolute bioavailability of kaemp-ferol-3-O-glucoside was not calculated because the elimination rate constant could not be estimated. These results may be applied to the basic data in a further study in order to develop functional foods or herbal medicinal products. 

Keywords

bioavailability; kaempferol-3-O-glucoside; monotropein; pharmacokinetic; quercetin-4’-O-glucoside

Cite and Share

Bo Ram Choi,Jae Sung Pyo,Mi Seon Yeo,Min-Gul Kim,Yu Seob Shin,Yu Seob Shin,Sung Won Lee,Chul Young Kim,Insuk So,Hye Kyung Kim,Jong Kwan Park. COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS . Journal of Men's Health. 2020. 16(SP1);57-70.

References

1. Makker K, Agarwal A, Sharma R. Oxidative stress & male infertility. Indian J Med Res 2009;129(4):357–67.

2. Dohle G, Colpi G, Hargreave T, et al. EAU guidelines on male infertility. Eur Urol 2005; 48(5):703–11. https://doi.org/10.1016/j.eururo. 2005. 06.002

3. Bae WJ, Ha U, Choi JB, et al. Protective effect of decursin extracted from Angelica gigas in male infertility via Nrf2/HO-1 signaling pathway. Oxid Med Cell Longev 2016;2016:1–9. https://doi.org/ 10.1155/2016/5901098

4. Clark NA, Will M, Moravek MB, et al. A system-atic review of the evidence for complementary and alternative medicine in infertility. Int J Gynaecol Obstet 2013;122(3):202–6. https://doi. org/10.1016/j.ijgo.2013.03.032

5. Zhang Z, Zhang Q, Yang H, et al. Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and pre-vents bone loss in ovariectomized mice. Fitoterapia 2016;110:166–72. https://doi.org/10.1016/j.fitote. 2016.03.013

6. Yoshikawa M, Yamaguchi S, Nishisaka H, et al. Chemical constituents of Chinese natural medi-cine, Morindae Radix, the dried roots of Morinda officinalis How: Structures of morindolide and morofficinaloside. Chem Pharm Bull (Tokyo) 1995;43(9):1462–5. https://doi.org/10.1248/cpb. 43.1462

7. Zhu M, Wang C, Wang X, et al. Extraction of polysaccharides from Morinda officinalis by response surface methodology and effect of the polysaccharides on bone-related genes. Carbohydr Polym 2011;85(1):23–8. https://doi.org/10.1016/j. carbpol.2011.01.016

8. Yang Z, Hu J, Zhao M. Isolation and quantitative determination of inulin-type oligosaccharides in roots of Morinda officinalis. Carbohydr Polym 2011;83(4):1997–2004. https://doi.org/10.1016/j. carbpol.2010.11.006

9. Choi J, Lee KT, Choi MY, et al. Antinociceptive, anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis. Biol Pharm Bull 2005;28(10):1915–8. https://doi.org/10.1248/bpb.28.1915

 10. Shin JS, Yun KJ, Chung KS, et al. Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-kappaB inactiva-tion. Food Chem Toxicol 2013;53:263–71. https://doi.org/10.1016/j.fct.2012.12.013

 11. Yen FL, Wu TH, Lin LT, et al. Concordance between antioxidant activities and flavonol con-tents in different extracts and fractions of Cuscuta chinensis. Food Chem 2008;108(2):455–62. https://doi.org/10.1016/j.foodchem.2007.10.077

 12. Umehara K, Nemoto K, Ohkubo T, et al. Isolation of a new 15-membered macrocyclic glycolipid lac-tone, Cuscutic Resinoside a from the seeds of Cuscuta chinensis: A stimulator of breastcancer cell proliferation. Planta Med 2004;70(4):299–304. https://doi.org/10.1055/ s-2004-818939

 13. Bao X, Wang Z, Fang J, et al. Structural features of an immunostimulating and antioxidant acidic polysaccharide from the seeds of Cuscuta chinen-sis. Planta Med 2002;68(3):237–43. https://doi. org/10.1055/s-2002-23133

 14. Wang Z, Fang JN, Ge DL, et al. Chemical charac-terization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam. Acta Pharmacol Sin 2000;21(12):1136–40.

 15. Donnapee S, Li J, Yang X, et al. Cuscuta chinensis Lam.: A systematic review on ethnopharmacol-ogy, phytochemistry and pharmacology of an important traditional herbal medicine. J Ethnopharmacol 2014;157:292–308. https://doi. org/10.1016/j.jep.2014.09.032

 16. Yen FL, Wu TH, Lin LT, et al. Nanoparticles for-mulation of Cuscuta chinensis prevents acetamin-ophen-induced hepatotoxicity in rats. Food Chem Toxicol2008;46(5):1771–7. https://doi.org/ 10.1016/j.fct.2008.01.021

 17. Marotti M, Piccaglia R. Characterization of flavonoids in different cultivars of onion (Allium cepa L.). J Food Sci 2002;67(3): 1229–32. https://doi.org/10.1111/j.1365-2621. 2002.tb09482.x

 18. Wiczkowski Wa, Nèmeth K, Buciñski A, et al. Bioavailability of quercetin from flesh scales and dry skin of onion in rats. Pol J Food Nutr Sci 2003;12(53):95–9.

 19. Olsson ME, Gustavsson KE, Vagen IM. Quercetin and isorhamnetin in sweet and red cultivars of onion (Allium cepa L.) at harvest, after field cur-ing, heat treatment, and storage. J Agric Food Chem 2010;58(4):2323–30. https://doi.org/10. 1021/jf9027014

 20. Slimestad R, Fossen T, Vagen IM. Onions: A source of unique dietary flavonoids. J Agric Food Chem 2007;55(25):10067–80. https://doi.org/10. 1021/jf0712503

 21. Singh BN, Singh BR, Singh RL, et al. Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities. Food Chem Toxicol 2009;47(6):1161–7. https://doi.org/10. 1016/ 

j. fct. 2009.02.004

 22. Soni KK, Zhang LT, You JH, et al. The effects of MOTILIPERM on cisplatin induced testicular toxicity in Sprague-Dawley rats. Cancer Cell Int 2015;15:121. https://doi.org/10.1186/s12935-015-0274-1

 23. Soni KK, Zhang LT, Choi BR, et al. Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways. Pharm Biol 2018;56(1):94–103. https://doi.org/10.1080/1388 0209.2017.1421672

 24. Soni KK, Shin YS, Choi BR, et al. Protective effect of DA-9401 in finasteride-induced apopto-sis in rat testis: Inositol requiring kinase 1 and

c- Jun N-terminal kinase pathway. Drug Des Devel Ther 2017;11:2969–79.

25. T suruma T, Sahara H, Takenouchi M, et al. Synthetic sulfonolipids deduced from sulfonoqui-novosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats. Transplant Proc 2004;36(7):1965–9.

26. Suyama Y, Handa O, Naito Y, et al. Mucus reduc-tion promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats. Biochem Biophys Res Commun 2018;498(1):228–33. https://doi. org/10.1016/j.bbrc.2018.02.202

 27. Mekjaruskul C, Jay M, Sripanidkulchai B, et al. Pharmacokinetics, bioavailability, tissue distribu-tion, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. Drug Metab Dispos 2012;40(12): 2342–53.

 28. Li X, Wang G, Sun J, et al. Pharmacokinetic and absolute bioavailability study of total panax noto-ginsenoside, a typical multiple constituent tradi-tional chinese medicine (TCM) in rats. Biol Pharm Bull 2007;30(5):847–51.

 29. Liu J, Zou S, Liu W, et al. An established HPLC-MS/MS method for evaluation of the influence of salt processing on pharmacokinetics of six compounds in cuscutae semen. Molecules 2019; 24(13):2502.

 30. Li C, Dong J, Tian J, et al. LC/MS/MS determina-tion and pharmacokinetic study of iridoid glyco-sides monotropein and deacetylasperulosidic acid isomers in rat plasma after oral adminis-tration of Morinda officinalis extract. Biomed Chromatogr 2016;30(2):163–8. https://doi.org/10. 1002/bmc.3532

 31. Zhou Q, Yan H, Li R, et al. Quantitative determi-nation of monotropein in rat plasma and tissue by LC–MS/MS and its application to pharmacoki-netic and tissue distribution studies. Rev Bras Farmacogn 2018;28(4):451–6.

 32. Li L, Brunner I, Han AR, et al. Pharmacokinetics of α-mangostin in rats after intravenous and oral application. Mol Nutr Food Res 2011;55(S1): S67–74. https://doi.org/10.1002/mnfr.201000511

 33. Wang F, Cao J, Hao J, et al. Pharmacokinetics, bioavailability and tissue distribution of genipo-side following intravenous and peroral adminis-tration to rats. Biopharm Drug Dispos 2014; 35(2):97–103.

 34. Lee HW, Kil KJ, Lee MS. Ginseng for improving semen quality parameters: A systematic review. World J Mens Health 2020;38:1–10. https://doi. org/10.5534/wjmh.190125

 35. Yoon YE, Kim TY, Shin TE, et al. Validation of SwimCount™, a novel home-based device that detects progressively motile spermatozoa:Correlation with world health organization 5th semen analysis. World J Mens Health 2020;38: 191–7. https://doi.org/10.5534/wjmh. 180095

 36. Park HJ, Koo YK, Park MJ, et al. Restoration of spermatogenesis using a new combined herbal formula of epimedium koreanum nakai and angelica gigas nakai in an luteinizing hormone- releasing hormone agonist-induced rat model of male infertility. World J Mens Health 2017;35: 170–7. https://doi.org/10.5534/wjmh.17031

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Directory of Open Access Journals (DOAJ) DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.

SCImago The SCImago Journal & Country Rank is a publicly available portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database (Elsevier B.V.)

Publication Forum - JUFO (Federation of Finnish Learned Societies) Publication Forum is a classification of publication channels created by the Finnish scientific community to support the quality assessment of academic research.

Scopus: CiteScore 0.7 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Norwegian Register for Scientific Journals, Series and Publishers Search for publication channels (journals, series and publishers) in the Norwegian Register for Scientific Journals, Series and Publishers to see if they are considered as scientific. (https://kanalregister.hkdir.no/publiseringskanaler/Forside).

Submission Turnaround Time

Conferences

Top