Main Article Content
male, metabolic syndrome, occupational population, elderly
This study was conducted to explore the prevalence of metabolic syndrome and identify associated risk factors in an elderly male occupational population in Taipei, Taiwan.
A total of 2734 healthy subjects over age 65 voluntarily presented to a teaching hospital for a physical check-up in 2010. Demographic data and blood test results were collected. Metabolic syndrome was diagnosed according to NCEP ATP III criteria.
The mean age of study participants was 74.4±6.6 years. The prevalence of metabolic syndrome was estimated at 29.9% (95%CI: 28.2%-31.6%). After adjustment for confounding factors, higher body-mass index (OR=1.50, 95%CI 1.41–1.62), higher mean body fat (% of total mass, OR=1.11, 95%CI: 1.04–1.20), elevated serum uric acid (OR=1.13, 95%CI: 1.02–1.26), and elevated alanine aminotransferase (OR=1.01, 95%CI: 1.00–1.02), and sedentary lifestyle (yes vs. no, OR=1.22, 95%CI: 1.09–1.37) were identified as the most significant risk factors associated with metabolic syndrome.
The prevalence of metabolic syndrome is related to several cardiovascular risk factors. Health initiatives directed towards preventing and treating metabolic syndrome could significantly reduce the prevalence of diabetes and cardiovascular disease in this older population.
2. Misra A, Khurana L. Obesity and the metabolic syndrome in developing countries. J Clin Endocrinol Metab 2008;93: S9–S30.
3. Liu M, Wang J, Bin J, et al. Increasing prevalence of metabolic syndrome in a Chinese elderly population: 2001-2010. PloS ONE 2013;8:e66233.
4. Nevajda B, Mestrovic AH, Bilic M, et al. Prevalence of the metabolic syndrome in the old institutionalized people in Zagreb, Croatia. Coll Antropol 2013;31:203–206.
5. Chen YF, Hu YC, Chen HC, et al. Clinical implications in the prevalence and associated cardiovascular fac-tors of elevated serum alanine aminotransferase levels among the elderly agricultural and fishing population in Taipei, Taiwan: Experience at a teaching hospital. J Invest Med 2014;62:88–96.
6. Jang SY, Kim IH, Ju EY, et al. Chronic kidney disease and metabolic syndrome in a general Korean population: The Third Korea National Health and Nutrition Examination Survey (KNHANES III) Study. J Public Health 2010;32:538–6.
7. Grundy SM, Cleeman JI, Daniels SE, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735–52.
8. Sachdeva S, Khan Z, Ansari MA, et al. Lifestyle and gallstone disease: Scope for primary prevention. Indian J Community Med 2011;36:263–7.
9. Chan YH. Multinomial logistic regression. Singapore Med J 2005;46:259–9.
10. Gundogan K, Bayram F, Gedik V, et al. Metabolic syndrome prevalence according to ATP III and IDF criteria and related factors in Turkish adults. Arch Med Sci 2013;9:243–53.
11. Erem C, Hacihasanoglu A, Deger O, et al. Prevalence of metabolic syndrome and associated risk factors among Turkish adults: Trabzon MetS study. Endocrine 2008;33:9–20.
12. Clarke J, Janssen I. Sporadic and bouted physical activity and the metabolic syndrome in adults. Med Sci Sports Exerc 2014;46:76–83.
13. Levine JA. Nonexercise activity thermogenesis--liberating the life-force. J Int Med 2007;262:273–87.
14. Tremblay MS, Warburton DER, Janssen I, et al. New Canadian physical activity guideline. Appl Physiol Nutr Metab 2011;36:36–46.
15. See LC, Kuo CF, Chuang FH, et al. Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. J Rheumatol 2009;36;1691–98.
16. Lim JH, Kim YK, Kim YS, et al. Relationship between serum uric acid levels, metabolic syndrome, and arterial stiffness in Korean. Korean Circ J 2010;40:314–20.
17. Yoo TW, Sung KC, Shin HS, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J 2005;69:928–33.
18. Nakagawa T, Cirillo P, Sato W, et al. The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med 2008;3:313–18.
19. Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006;290: F625–F631.
20. Gu D, Reynolds K, Wu X, et al. Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 2005;365:1398–405.
21. Misra A, Vikram NK. Insulin resistance syndrome (metabolic syndrome) and obesity in Asian Indians: evidence and implications. Nutrition 2004;20:482–91.
22. Misra A, Vikram NK. Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots. Nutrition 2003;19:457–66.
23. Dickinson S, Colagiuri S, Faramus E, et al. Post-prandial hyperglycemia and insulin sensitivity differ among lean young adults of different ethnicities. J Nutr 2002;132:2574–79.
24. Liu Z. Obesity and metabolic syndrome. North Am J Med Sci 2009;2:88–89.
25. The Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NECP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.
26. Chen ZW, Chen LY, Dai HL, et al. Relationship be-tween alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. Zhejiang Univ Sci B 2008;9:616–22.
27. Fu CC, Chen MC, Li YM, et al. The risk factors for ultrasound-diagnosed non-alcoholic fatty liver dis-ease among adolescents. Ann Acad Med Singapore 2009;38:15–17.
28. Oh SY, Cho YK, Kang MS, et al. The association between increased alanine aminotransferase activity and metabolic factors in nonalcoholic fatty liver disease. Metabolism 2006;55:1604–609.
29. Kitiyakara C, Yamwong S, Cheepudomwit S, et al. The metabolic syndrome and chronic kidney disease in a Southeast Asian cohort. Kidney Int 2007;71:693–700.
30. Tan CE, Ma S, Wai D, et al. Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome to Asians? Diabetes Care 2004;27:1182–86.
31. Fan JG, Zhu J, Li XJ, et al. Fatty liver and the metabolic syndrome among Shanghai adults. J Gastroenterol Hepatol 2005;20:1825–32.
32. Ko GT, Tang JS. Metabolic syndrome in the Hong Kong community: the United Christian Nethersole Community Health Service primary healthcare programme, 2001-2002. Singapore Med J 2007;48:1111–16.
33. Shin MH, Kweon SS, Choi JS, et al. Average volume of alcohol consumed, drinking patterns, and metabolic syndrome in older Korean adults. J Epidemiol 2013;23:122–31.
34. Carriere I, Pérès K, Ancelin ML, et al. Metabolic syndrome and disability: Findings from the Prospective Three-City Study. J Gerontol A Biol Sci Med Sci 2013 Jul 5.
35. Li JB, Wang X, Zhang JX, et al. Metabolic syndrome: prevalence and risk factors in southern China. J Int Med Res 2010;38:1142–48.
36. Chiou WK, Wang MH, Huang DH, et al. The relationship between serum uric acid level and metabolic syndrome: Differences by sex and age in Taiwanese. J Epidemiol 2010;20:219–24.
37. Zuo h, Shi Z, Hu X, et al. Prevalence of metabolic syndrome and factors associated with its components in Chinese adults. Metabolism 2009;58:1102–108.
38. Rho YH, Woo JH, Choi SJ, et al. Association between serum uric acid and the Adult Treatment Panel III-defined metabolic syndrome: Results from a single hospital database. Metabolism 2008;57:71–76.
39. Ford ES. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care 2005;28:2745–49.
40. Park HS, Oh SW, Cho SI, et al. The metabolic syndrome and associated lifestyle factors among South Korean adults. Int J Epidemiol 2004;33:328–36.
41. Gupta A, Gupta R, Sarna M, et al. Prevalence of diabetes, impaired fasting glucose and insulin resistance syndrome in an urban Indian population. Diabetes Res Clin Pract 2003;61:69–76.
42. Azizi F, Salehi P, Etemadi A, et al. Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract 2003;61:29–37.
43. Al-Lawati JA, Mohammed AJ, Al-Hinai HQ, et al. Prevalence of the metabolic syndrome among Omani adults. Diabetes Care 2003;26:1781–85.
44. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356–59.
45. Misra A, Pandey RM, Devi JR, et al. High prevalence of diabetes, obesity and dyslipidaemia in urban slum population in northern India. Int J Obes Relat Metab Disord 2001;25:1722–29.