RT  - Journal of Men's Health
ID  - 10.15586/jomh.v16iSP1.235
T1  - COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS
A1  - Bo Ram Choi
A1  - Jae Sung Pyo
A1  - Mi Seon Yeo
A1  - Min-Gul Kim
A1  - Yu Seob Shin
A1  - Yu Seob Shin
A1  - Sung Won Lee
A1  - Chul Young Kim
A1  - Insuk So
A1  - Hye Kyung Kim
A1  - Jong Kwan Park
K1  - bioavailability; kaempferol-3-O-glucoside; monotropein; pharmacokinetic; quercetin-4’-O-glucoside
YR  - 2020
SP  - 57
AB  - <p class="ql-align-justify"><strong>Background and Objective</strong></p><p class="ql-align-justify">This study has evaluated the pharmacokinetic parameters and bioavailabilities of monotropein, kae-mpferol-3-O-glucoside, and quercetin-4’-O-glucoside after administration of MOTILIPERM in rats.</p><p class="ql-align-justify"><strong>Material and Methods</strong></p><p class="ql-align-justify">Following the administration of MOTILIPERM, the plasma concentrations of each compound in rats were simultaneously determined by using liquid chromatography tandem mass spectrometry (LC-MS/MS).</p><p class="ql-align-justify"><strong>Results</strong></p><p class="ql-align-justify">The pharmacokinetic parameters of monotropein in rats were AUCinf 20,020.44±3944.67 and 11,915.53±1190.91 min·ng/mL and Cmax 286.99±38.37 and 56.23±9.02 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of kaempferol-3-O-glucoside in rats were AUCinf 287.86±126.17 min·ng/mL and not estimated; Cmax 5.80±1.87 and 1.24±0.41 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of querce-tin-4’-O-glucoside in rats were AUCinf 511.38±248.11 and 481.44±65.72 min·ng/mL; Cmax 10.72±2.70 and 2.83±0.34 ng/mL for intravenous and oral administration, respectively.&nbsp;</p><p class="ql-align-justify"><strong>Conclusion</strong></p><p class="ql-align-justify">The absolute bioavailabilities of monotropein and quercetin-4’-O-glucoside for oral administration were evaluated and calculated as 3.0 and 4.7%, respectively. The absolute bioavailability of kaemp-ferol-3-O-glucoside was not calculated because the elimination rate constant could not be estimated. These results may be applied to the basic data in a further study in order to develop functional foods or herbal medicinal products.&nbsp;</p>