Gastrointestinal (GI) cancer is the prevalent cause of global cancer deaths, and its effective treatments are lacking. This common malignancy can be identified through hematomas or black stools. It includes the cancers of digestive system, i.e., esophagus, stomach, liver, pancreas and colon. It is surgically removed followed by the conservative management. The incidence of GI cancer in men is 2–3 times higher compared to women. This higher prevalence in men is because of the involvement of sex steroid hormones via androgen receptor. The clinical case studies in men are continuously being conducted, however there are unanswered questions regarding the therapeutics. In this review, future therapeutic strategies of GI cancer and gastrointestinal stromal tumor (GIST) are being encompassed.