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COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS 

  • Bo Ram Choi1,†
  • Jae Sung Pyo2,†
  • Mi Seon Yeo2
  • Min-Gul Kim3
  • Yu Seob Shin6
  • Yu Seob Shin1
  • Sung Won Lee4
  • Chul Young Kim5
  • Insuk So7
  • Hye Kyung Kim2
  • Jong Kwan Park6

1Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea

2College of Pharmacy and Brain Busan 21 program, Kyungsung University, Busan, Republic of Korea

3Department of Pharmacology, School of Medicine, Jeonbuk National University, Jeonju, Republic of Korea

4Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

5College of Pharmacy, Hanyang University, Ansan, Republic of Korea

6Department of Urology, Jeonbuk National University and Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Jeonbuk National University Hospital, Jeonju, Republic of Korea

7Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, South Korea

DOI: 10.15586/jomh.v16iSP1.235 Vol.16,Issue SP1,April 2020 pp.57-70

Published: 01 April 2020

*Corresponding Author(s): Hye Kyung Kim E-mail: fiona30@ks.ac.kr
*Corresponding Author(s): Jong Kwan Park E-mail: rain@jbnu.ac.kr

† These authors contributed equally.

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Abstract

Background and Objective

This study has evaluated the pharmacokinetic parameters and bioavailabilities of monotropein, kae-mpferol-3-O-glucoside, and quercetin-4’-O-glucoside after administration of MOTILIPERM in rats.

Material and Methods

Following the administration of MOTILIPERM, the plasma concentrations of each compound in rats were simultaneously determined by using liquid chromatography tandem mass spectrometry (LC-MS/MS).

Results

The pharmacokinetic parameters of monotropein in rats were AUCinf 20,020.44±3944.67 and 11,915.53±1190.91 min·ng/mL and Cmax 286.99±38.37 and 56.23±9.02 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of kaempferol-3-O-glucoside in rats were AUCinf 287.86±126.17 min·ng/mL and not estimated; Cmax 5.80±1.87 and 1.24±0.41 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of querce-tin-4’-O-glucoside in rats were AUCinf 511.38±248.11 and 481.44±65.72 min·ng/mL; Cmax 10.72±2.70 and 2.83±0.34 ng/mL for intravenous and oral administration, respectively. 

Conclusion

The absolute bioavailabilities of monotropein and quercetin-4’-O-glucoside for oral administration were evaluated and calculated as 3.0 and 4.7%, respectively. The absolute bioavailability of kaemp-ferol-3-O-glucoside was not calculated because the elimination rate constant could not be estimated. These results may be applied to the basic data in a further study in order to develop functional foods or herbal medicinal products. 

Keywords

bioavailability; kaempferol-3-O-glucoside; monotropein; pharmacokinetic; quercetin-4’-O-glucoside

Cite and Share

Bo Ram Choi,Jae Sung Pyo,Mi Seon Yeo,Min-Gul Kim,Yu Seob Shin,Yu Seob Shin,Sung Won Lee,Chul Young Kim,Insuk So,Hye Kyung Kim,Jong Kwan Park. COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS . Journal of Men's Health. 2020. 16(SP1);57-70.

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