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Original Research

Open Access

EFFECT OF A COMBINATION OF OMEGA-3 AND ORAL TESTOSTERONE UNDECANOATE ON SERUM TESTOSTERONE LEVELS IN PATIENTS WITH TESTOSTERONE DEFICIENCY

  • Min Gu Park1
  • Dae Yeon Cho2
  • Sung Yong Cho3
  • Jeong Kyun Yeo1

1Department of Urology, College of Medicine, Inje University, Seoul Paik Hospital, Seoul, Republic of Korea

2Department of Urology, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Republic of Korea

3Department of Urology, College of Medicine, Inje University, Ilsan Paik Hospital, Ilsan, Republic of Korea

DOI: 10.15586/jomh.v16iSP1.247 Vol.16,Issue SP1,April 2020 pp.43-51

Published: 01 April 2020

*Corresponding Author(s): Jeong Kyun Yeo E-mail: yeoluvk@hanmail.net

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Abstract

Background and Objective

Oral testosterone undecanoate (TU) is taken up by the intestinal lymphatic system. Thus, the dietary lipid content affects TU absorption. This study aimed to investigate the effect of combined omega-3 fatty acids (OMG3) and oral TU on serum testosterone levels in patients with testosterone deficiency (TD).

Material and Methods

Sixty consecutive patients with symptomatic TD and low serum total testosterone (TT) levels were enrolled and divided randomly into group 1, oral TU 80 mg twice daily for 30 days, and group 2, OMG3 and oral TU 80 mg twice daily for 30 days. Serum TT concentrations and male function scales were evaluated at baseline and 7 days and 1 month post-treatment. Dietary habits were investigated, and caloric and lipid intakes were measured during the treatment periods.

Results

The groups did not differ in terms of mean age, body mass index, comorbidities, initial serum TT con-centrations, and IIEF/AMS scores. After 7 days and 1 month of treatment, serum TT concentrations were only significantly increased in group 2. The degree of increase in TT was higher in group 2 than in group 1 at 7 days and 1 month, although the difference was only significant at 1 month. Both groups exhibited significant improvements in IIEF and AMS scores at 1 month, with no significant inter-group difference. A diet diary study revealed that 23.3% and 20% of both groups did not eat breakfast and both groups consumed <12 g of lipids and <500 Kcals, without significance differences.

Conclusion

We observed a significant increase in serum TT concentration after 1 month of treatment with the com-bination of OMG3 and oral TU, compared to with oral TU monotherapy. Therefore, the combination of OMG3 and oral TU can be considered for the treatment of TD in Korean patients with irregular break-fast habits. 

Keywords

lipid; omega-3; testosterone; testosterone deficiency; testosterone undecanoate 

Cite and Share

Min Gu Park,Dae Yeon Cho,Sung Yong Cho,Jeong Kyun Yeo. EFFECT OF A COMBINATION OF OMEGA-3 AND ORAL TESTOSTERONE UNDECANOATE ON SERUM TESTOSTERONE LEVELS IN PATIENTS WITH TESTOSTERONE DEFICIENCY. Journal of Men's Health. 2020. 16(SP1);43-51.

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