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Original Research

Open Access

LY6E level associated with smoking as risk for lung cancer patients susceptible to COVID-19

  • Ying-Yu Ma1,2,3
  • Jing-Xing Si3
  • Xiao-Zhou Mou3
  • Hai Zou1,*,

1Department of Critical Care, Fudan University Shanghai Cancer, 200032 Shanghai, China

2Cancer Center, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310014 Hangzhou, Zhejiang, China

3Clinical research institute, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310014 Hangzhou, Zhejiang, China

DOI: 10.22514/jomh.2023.044 Vol.19,Issue 6,June 2023 pp.20-25

Submitted: 13 March 2023 Accepted: 19 April 2023

Published: 30 June 2023

*Corresponding Author(s): Hai Zou E-mail: zouhai@fudan.edu.cn

Abstract

Studies revealed that cancer patients seemed more susceptible to COVID-19 and the clinical symptoms were serious. A recent study depicted that lymphocyte antigen 6 complex, locus E (LY6E) might inhibit coronavirus entry into cells by interfering with the membrane fusion process mediated through spike protein, and potently restricting the SARS-CoV-2 (Severe acute respiratory syndrome-associated coronavirus 2) infection. LY6E mRNA level in lung cancer was detected by publicly available datasets. Patient-specific features were used to analyze the potential factors that could affect LY6E level. Analysis of association between LY6E level and immune infiltration was also performed. In present study, it was found that smoker with lung adenocarcinoma showed lower LY6E level than non-smoker (p < 0.05). In LUSC (lung squamous cell carcinoma) patients, reformed smokers showed higher LY6E than smokers (p < 0.05). These results suggested that smoke can be a risk susceptible to COVID-19 in lung cancer patients. Further studies exhibited that LY6E was positively associated with immune cell infiltration in lung adenocarcinoma, indicating that LY6E may influence the infection severity of COVID-19 in lung cancer patients. In summary, smoke may downregulate LY6E level and exacerbate infection and deterioration of COVID-19 in lung cancer patients.


Keywords

LY6E; Smoke; Lung cancer; Susceptibility; COVID-19


Cite and Share

Ying-Yu Ma,Jing-Xing Si,Xiao-Zhou Mou,Hai Zou. LY6E level associated with smoking as risk for lung cancer patients susceptible to COVID-19. Journal of Men's Health. 2023. 19(6);20-25.

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