Title
Author
DOI
Article Type
Special Issue
Volume
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Enhancing androgen ablation response in metastatic hormone-sensitive prostate cancer: the benefits of transurethral resection of the prostate
1Department of Urology, The First Affiliated Hospital of Soochow University, 215006 Suzhou, Jiangsu, China
2Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, 221000 Xuzhou, Jiangsu, China
DOI: 10.22514/jomh.2023.056 Vol.19,Issue 7,July 2023 pp.39-44
Submitted: 25 November 2022 Accepted: 15 March 2023
Published: 30 July 2023
*Corresponding Author(s): Chang-Song Pei E-mail: 20224132064@stu.suda.edu.cn
† These authors contributed equally.
Presently, there is limited data on the potential survival benefits of transurethral resection of the prostate (TURP) in patients with metastatic hormone-sensitive prostate cancer (mHSPCa). In this study, we aimed to assess the effects of TURP on the survival of mHSPCa patients. Of the 59 patients diagnosed with mHSPCa included, 28 received androgen deprivation therapy (ADT) alone, and the remaining received TURP plus ADT. Their time to biochemical progression (TBCP) and progression-free survival (PFS) were analyzed. Our results showed that for a median follow-up time of 15 (range, 3–40) months and 21 (range, 6–39) months for the ADT group and the TURP group, respectively, the TURP group exhibited significantly longer TBCP than the ADT group (p = 0.020). In addition, patients in the TURP group had numerically longer PFS, although the difference between the two groups was not significantly different (p = 0.110). Cox multivariate analysis indicated that longer TBCP was independently associated with TURP (p = 0.032) and lower Gleason scores (p = 0.001). Altogether this study showed that TURP could prolong TBCP and potentially improve the PFS of mHSPCa patients. However, further studies with a larger sample size are needed to confirm these findings.
Metastasis prostate cancer; Hormone sensitive; Transurethral resection of the prostate; Progression-free survival; Time to castration resistance
Yan Zhao,Jie Liang,Qian Wang,Jing-Yi Cao,Zhi-Xiang Yin,Han-Yong Feng,Yu-Hao Peng,Nian-Xin Gai,Chang-Song Pei. Enhancing androgen ablation response in metastatic hormone-sensitive prostate cancer: the benefits of transurethral resection of the prostate. Journal of Men's Health. 2023. 19(7);39-44.
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