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A randomized controlled trial of combined low-intensity extracorporeal shockwave therapy and Dapoxetine use in the management of lifelong premature ejaculation

  • Kazim Dogan1,*,
  • Mehmet Taskiran2

1Department of Urology, Faculty of Medicine, Istinye University, 34394 Istanbul, Turkey

2Department of Urology, Gaziantep Private Hatem Hospital, 27010 Gaziantep, Turkey

DOI: 10.22514/jomh.2023.076 Vol.19,Issue 8,August 2023 pp.92-98

Submitted: 03 May 2023 Accepted: 12 July 2023

Published: 30 August 2023

*Corresponding Author(s): Kazim Dogan E-mail:


We aimed to evaluate the efficacy of combined low-intensity extracorporeal shockwave therapy (LI-ESWT) and dapoxetine administration for the treatment of lifelong premature ejaculation (LPE) in comparison to LI-ESWT and dapoxetine alone. In the randomized controlled trial, 212 men diagnosed with LPE were enrolled. The participants were randomized into four subgroups: control (n = 50), dapoxetine (n = 56), LI-ESWT (n = 50) and LI-ESWT + dapoxetine (n = 56). The intravaginal ejaculation latency (IELT), premature ejaculation profile (PEP), and Global Impression of Change (GIC) were evaluated. There were substantial improvements in the fold-increase of the IELT (F-IELT), and PEP and GIC-I scores in both the dapoxetine (p < 0.001) and LI-ESWT + Dapoxetine (p < 0.001) groups than in the control and LI-ESWT groups. Although the LI-ESWT group demonstrated a minor improvement in the F-IELT score (p = 0.04), there were no noticeable improvements in the PEP (p = 0.12) and GIC-I (p = 0.15) scores. In conclusion, a combination of dapoxetine administration and LI-ESWT might be more effective in treating LPE than LI-ESWT or dapoxetine alone, indicating a potential synergistic effect.


Premature ejaculation; Therapy; Dapoxetine; LI-ESWT; IELT

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Kazim Dogan,Mehmet Taskiran. A randomized controlled trial of combined low-intensity extracorporeal shockwave therapy and Dapoxetine use in the management of lifelong premature ejaculation. Journal of Men's Health. 2023. 19(8);92-98.


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