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Original Research

Open Access

Alisma orientale extract inhibits cell proliferation by promoting oxidative stress and apoptosis in prostate cancer cells

  • Junwei Xu1
  • Ning Qin2,*,
  • Wenbo Jiang3
  • Tao Chen1

1Department of Traditional Chinese Medicine, Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China

2Department of Medical Nursing Teaching and Research, Nantong Health College of Jiangsu Province, 226001 Nantong, Jiangsu, China

3Department of Cardiovascular Medicine, Suqian Hospital of TCM, 223800 Suqian, Jiangsu, China

DOI: 10.22514/jomh.2023.122 Vol.19,Issue 11,November 2023 pp.109-115

Submitted: 26 August 2023 Accepted: 20 October 2023

Published: 30 November 2023

*Corresponding Author(s): Ning Qin E-mail:


Prostate cancer is a prevalent malignancy in men, necessitating the development of more effective treatment drugs. Alisma is commonly used in clinical settings for various ailments, including tumors. However, its mechanism of action in prostate cancer cells remains unclear. This study aimed to clarify the effects of Alisma orientale extract (AOE) on prostate cancer. Our results showed that AOE inhibited prostate cancer cell growth and induced apoptosis while promoting oxidative stress. Mechanistically, AOE modulated the p38/nuclear factor kappa-B (NF-κB) pathway to inhibit prostate cancer progression. Taken together, these findings suggest that AOE could serve as a potential treatment for prostate cancer.


Prostate cancer; Alisma orientale extract (AOE); Apoptosis; Oxidative stress; p38/NF-κB pathway

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Junwei Xu,Ning Qin,Wenbo Jiang,Tao Chen. Alisma orientale extract inhibits cell proliferation by promoting oxidative stress and apoptosis in prostate cancer cells. Journal of Men's Health. 2023. 19(11);109-115.


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