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Original Research

Open Access

Effects of cancer type and sex on genetic testing for clinician recommendation and uptake

  • Emerson Delacroix1,2,*,
  • Erika N. Hanson3
  • Sarah Austin4
  • Grant Carr5
  • Kelley M. Kidwell5
  • Jennifer J. Griggs4,6
  • Elena Martinez Stoffel4
  • Lynette Hammond Gerido1
  • Sarah T. Hawley1,2,4
  • Elizabeth Bacon2
  • Ken Resnicow1,2

1Department of Health Behavior Health Education, University of Michigan, Ann Arbor, MI 48109, USA

2Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI 48109, USA

3Department of Human Genetics, Michigan Medicine, Ann Arbor, MI 48109, USA

4Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI 48109, USA

5Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA

6Department of Health Management and Policy, University of Michigan, Ann Arbor, MI 48109, USA

DOI: 10.22514/jomh.2023.126 Vol.19,Issue 12,December 2023 pp.23-30

Submitted: 04 July 2023 Accepted: 05 September 2023

Published: 30 December 2023

*Corresponding Author(s): Emerson Delacroix E-mail: emmed@med.umich.edu

Abstract

This study investigated reasons for lower-than-expected uptake of germline genetic testing compared to national guidelines amongst adult patients with cancer, self-reporting clinician recommendation for genetic testing. Cross-sectional survey of 596 patients with a personal history of cancer, responded about their cancer diagnosis, physician recommendation for and status of genetic testing and demographics. Adjusting for potential confounding factors (cancer type, education, income and insurance status) male sex significantly decreased odds of receiving a clinical recommendation for genetic testing (Odds Ratio: 0.06; 95% Confidence Interval: 0.04–0.10). Females, with a diagnosis of breast cancer, were more likely to receive a recommendation than other cancer types (64.8% vs. 90.9%, p < 0.001). Participants who received a physician recommendation were significantly more likely to receive genetic testing (p < 0.001). Clinician recommendation is an important driver of genetic testing, necessitating efforts to increase clinician recommendations, particularly for males and patients with cancers other than breast.


Keywords

Adults; Cancer; Genetic testing; Genetic risk; Breast cancer; Prostate cancer; Adherence


Cite and Share

Emerson Delacroix,Erika N. Hanson,Sarah Austin,Grant Carr,Kelley M. Kidwell,Jennifer J. Griggs,Elena Martinez Stoffel,Lynette Hammond Gerido,Sarah T. Hawley,Elizabeth Bacon,Ken Resnicow. Effects of cancer type and sex on genetic testing for clinician recommendation and uptake. Journal of Men's Health. 2023. 19(12);23-30.

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