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Case Report

Open Access

Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms

  • Kyung Hwan Kim1,2
  • Yury Lee3
  • Ja Yoon Ku4
  • Hong Koo Ha1,2
  • Hyun Jun Park1,2,*,

1Department of Urology, Pusan National University School of Medicine, 49241 Busan, Republic of Korea

2Medical Research Institute of Pusan National University Hospital, 49241 Busan, Republic of Korea

3Department of Pathology, Pusan National University School of Medicine, 49241 Busan, Republic of Korea

4Department of Urology, Dongnam Inst. of Radiological & Medical Sciences, 46033 Busan, Republic of Korea

DOI: 10.22514/jomh.2024.015 Vol.20,Issue 1,January 2024 pp.114-119

Submitted: 13 September 2023 Accepted: 17 October 2023

Published: 30 January 2024

*Corresponding Author(s): Hyun Jun Park E-mail: joon501@pusan.ac.kr

Abstract

Paratesticular malignant mesothelioma (MM) is a rare tumor frequently associated with asbestos exposure. Therefore, we present an even rarer case of a 78-year-old male patient diagnosed with multiple primary neoplasms, including prostate cancer, lung cancer, paratesticular MM, and upper tract urothelial carcinoma. The patient initially presented with a painless testicular mass and had a notable medical history of prostate and lung cancers. Following physical examination and an ultrasound evaluation, he underwent radical right inguinal orchiectomy, which revealed paratesticular MM. The patient’s lung cancer recurrence and subsequent treatment coincided with periods of no MM recurrence. However, after the lung cancer treatment, the MM recurred multiple times within short intervals. This unique case indicates that systemic treatments for lung cancer, specifically cisplatin-based chemotherapy and atezolizumab immunotherapy, might also have an anti-tumor effect on paratesticular MM. Although MM combined with multiple primary neoplasms is challenging to treat and frequently recurs, treatments for other malignancies, as evidenced in this case, may have suppressive effects on the recurrence and metastasis of MM.


Keywords

Malignant mesothelioma; Multiple primary neoplasm; Testicular tumors


Cite and Share

Kyung Hwan Kim,Yury Lee,Ja Yoon Ku,Hong Koo Ha,Hyun Jun Park. Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms. Journal of Men's Health. 2024. 20(1);114-119.

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