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Original Research

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Association between lipid accumulation product index and lower urinary tract symptom—benign prostatic hyperplasia: a 7-year follow-up study

  • Shuqin Zhang1,2
  • Zhen Yao3
  • Shengyu Zhou2,4
  • Lisi Zhang2,5
  • Jiayu Liang6,*,

1Operating room, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China

2West China School of Nursing, Sichuan University, 610041 Chengdu, Sichuan, China

3Department of Urology, Tangdu Hospital, the Air Force Medical University, 710038 Xi’an, Shaanxi, China

4Department of Orthopedics, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China

5Department of Nephrology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China

6Department of Urology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China

DOI: 10.22514/jomh.2024.032

Submitted: 29 October 2023 Accepted: 28 November 2023

Online publish date: 12 March 2024

*Corresponding Author(s): Jiayu Liang E-mail: jiayu.liang@scu.edu.cn

Abstract

The distribution of adipose tissue plays a crucial role in the progression of lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH). This study was performed to explore the longitudinal association between the lipid accumulation product index (LAPI) and LUTS/BPH. Based on logistic and restricted cubic spline (RCS) regressions, data from the China Health and Retirement Longitudinal Study were used to evaluate the odds ratio (OR) and non-linear correlation between LAPI and LUTS/BPH. Subgroup and interactive analyses were adopted to determine the interactive effects of covariates. In addition, a 7-year retrospective cohort from 2011–2018 was constructed to investigate the longitudinal association. After data cleansing, this study included 3967 males aged >40 years in 2011. In the full model, high LAPI was significantly associated with prevalent LUTS/BPH (OR = 1.007; 95% CI (confidence interval): 1.001–1.013, p = 0.016). Furthermore, as a categorical variable, the ORs were 1.21 (95% CI = 0.91–1.62, p = 0.197) and 1.56 (95% CI = 1.09–2.23, p = 0.014) for the second and third tertile groups, respectively. No significant interactive effects were detected (all p for interaction > 0.05). The RCS regression revealed a linear association between LAPI and prevalent LUTS/BPH in the overall population (p for overall < 0.05) and an L-shaped association in males aged ≥60 years (p for non-linear = 0.006). In the 2011–2018 cohort, the ORs for the second and third tertile groups were 1.51 (95% CI = 1.11–2.04, p = 0.008) and 1.74 (95% CI = 1.21–2.50, p = 0.003) in the full models, respectively. All the sensitivity analyses supported similar findings. In conclusion, aging males with high LAPI have a higher risk of developing LUTS/BPH than their counterparts.


Keywords

Aging male; Benign prostatic hyperplasia; Lower urinary tract symptom; Lipid accumulation product index; CHARLS


Cite and Share

Shuqin Zhang,Zhen Yao,Shengyu Zhou,Lisi Zhang,Jiayu Liang. Association between lipid accumulation product index and lower urinary tract symptom—benign prostatic hyperplasia: a 7-year follow-up study. Journal of Men's Health. 2024.doi:10.22514/jomh.2024.032.

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