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Original Research

Open Access

Exploring the significance of glycosylation in prostate cancer subtyping through single-cell analysis

  • Shijun Tong1
  • Wenhui Zhu1
  • Jing Zhai1
  • Guanxiong Ding1,*,

1Department of Urology, Huashan Hospital, Fudan University, 200040 Shanghai, China

DOI: 10.22514/jomh.2024.036 Vol.20,Issue 3,March 2024 pp.32-44

Submitted: 05 June 2023 Accepted: 12 July 2023

Published: 30 March 2024

*Corresponding Author(s): Guanxiong Ding E-mail: 10111220030@fudan.edu.cn

Abstract

Prostate cancer impacts millions of men worldwide and causes significant disease burden. Glycosylation is the post-translational modification offering novel therapeutics for prostate cancer. The scRNA-seq data is combined with bulk RNA-seq data of prostate cancer to understand the glycosylation role and identify the therapeutic targets. This study aims to investigate the differences within tumor and the role of glycosylation. The findings confirm that glycosylation can establish multiple cell biomarkers and divide the cell subtypes of prostate cancer. The specific cell subtypes have diverse functions in cell interactions, transcript activity, prognosis and immunotherapy response, such as UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7+ (GALNT7+) epithelial cells and UDP Glucose Ceramide Glucosyltransferase+ (UGCG+) cancer associated macrophages. These outcomes assist in the better understanding of prostate cancer and provide new approach of the targeted therapy.


Keywords

Prostate cancer; Glycosylation; Single-cell analysis; Subtyping


Cite and Share

Shijun Tong,Wenhui Zhu,Jing Zhai,Guanxiong Ding. Exploring the significance of glycosylation in prostate cancer subtyping through single-cell analysis. Journal of Men's Health. 2024. 20(3);32-44.

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