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Original Research

Open Access

Relationship between electrocardiogram and findings of serum protein, transaminase and chest CT in male AIDS patients

  • Hong Lv1,*,
  • Ping Du1
  • Linyu Zeng1
  • Ziyuan Shi1
  • Pingping Zheng1

1Special Laboratory Medicine, Hangzhou Xixi Hospital, 310023 Hangzhou, Zhejiang, China

DOI: 10.22514/jomh.2024.046 Vol.20,Issue 3,March 2024 pp.121-129

Submitted: 11 January 2024 Accepted: 04 March 2024

Published: 30 March 2024

*Corresponding Author(s): Hong Lv E-mail: Lvhong_666@163.com

Abstract

To investigate the relationship between electrocardiogram (ECG) and findings of serum protein, transaminase and chest computed tomography (CT) in male acequired immune deficiency syndrome (AIDS) patients. 122 male AIDS patients were divided into groups according to serum protein, transaminase detection and chest CT results. ECG detection results of different groups were compared and analyzed. Among 122 male AIDS patients, 75 patients had abnormal ECGs, with a prevalence of 61.48%. According to serum protein detection results, the proportion of male AIDS patients with decreased albumin was the highest, 38.52%. Tachyarrhythmia was significantly more prevalent in the decreased albumin and increased globulin group than in the normal serum protein group (χ2 = 10.710, p = 0.001). The incidence of tachyarrhythmia in the albumin reduction group was significantly higher than in the normal serum protein group (χ2 = 9.387, p = 0.002). Transaminase test results showed 19.67% of patients had elevated glutamic pyruvic transaminase (ALT) and glutamic oxaloacetic transaminase (AST). In the elevated AST group, the tachyarrhythmia incidence was significantly higher (χ2 = 11.484, p = 0.001), and significantly higher in the elevated ALT and AST groups than in the normal transaminase group (χ2 = 9.102, p = 0.003). Chest CT examination showed, 48.36% of patients had pulmonary inflammation. Tachyarrhythmia incidence was significantly higher in the pulmonary inflammation group than in the normal CT examination group (χ2 = 8.437, p = 0.004). As compared to the normal CT group, tachyarrhythmia was significantly more prevalent in the pulmonary tuberculosis group (χ2 = 4.323, p = 0.038). The incidence of abnormal ECG in male AIDS patients is significant. The high incidence of abnormal ECG in male AIDS patients is closely associated with albumin reduction, ALT elevation and pulmonary infection. Electrocardiogram monitoring can provide valuable reference and guidance for clinical diagnosis and treatment.


Keywords

Male; AIDS; Electrocardiogram; Serum protein; Transaminase; Chest CT


Cite and Share

Hong Lv,Ping Du,Linyu Zeng,Ziyuan Shi,Pingping Zheng. Relationship between electrocardiogram and findings of serum protein, transaminase and chest CT in male AIDS patients. Journal of Men's Health. 2024. 20(3);121-129.

References

[1] Haeuser E, Serfes AL, Cork MA, Yang M, Abbastabar H, Abhilash ES, et al. Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018. BMC Medicine. 2022; 20: 488.

[2] Verdikt R, Bendoumou M, Bouchat S, Nestola L, Pasternak AO, Darcis G, et al. Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. EBioMedicine. 2022; 79: 103985.

[3] Waldrop D, Irwin C, Nicholson WC, Lee CA, Webel A, Fazeli PL, et al. The intersection of cognitive ability and HIV: a review of the state of the nursing science. Journal of the Association of Nurses in AIDS Care. 2021; 32: 306–321.

[4] Wairimu F, Ward NC, Liu Y, Dwivedi G. Cardiac Transplantation in HIV-positive patients: a narrative review. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2021; 87: 763–768.

[5] Köse E, Seyman D, Sarigül-Yildirim F, Yerlisu-Lapa T, Tercan-Kaas E. Bibliometric analysis of HIV and exercise literature based on scientific studies from 1990–2020. Iranian Journal of Public Health. 2021; 50: 2397–2410.

[6] Teer E, Dominick L, Mukonowenzou NC, Essop MF. HIV-related myocardial fibrosis: inflammatory hypothesis and crucial role of immune cells dysregulation. Cells. 2022; 11: 2825.

[7] Kipke J, Margevicius S, Kityo C, Mirembe G, Buggey J, Yun CH, et al. Sex, HIV status, and measures of cardiac stress and fibrosis in Uganda. Journal of the American Heart Association. 2021; 10: e018767.

[8] Kovacs L, Kress TC, Belin de Chantemèle EJ. HIV, combination antiretroviral therapy, and vascular diseases in men and women. JACC: Basic to Translational Science. 2022; 7: 410–421.

[9] Kitilya B, PrayGod G, Peck R, Changalucha J, Jeremiah K, Kavishe BB, et al. Levels and correlates of physical activity and capacity among HIV-infected compared to HIV-uninfected individuals. PLOS ONE. 2022; 17: e0262298.

[10] Miranda Pérez AA, Gutiérrez Pérez ME, Urraza Robledo AI, Delgadillo Guzmán D, Ruíz Flores P, López Márquez FC. Klotho-HIV and oxidative stress: the role of klotho in cardiovascular disease under hiv infection—a review. DNA and Cell Biology. 2020; 39: 1478–1485.

[11] Khanal S, Schank M, El Gazzar M, Moorman JP, Yao ZQ. HIV-1 latency and viral reservoirs: existing reversal approaches and potential technologies, targets, and pathways involved in HIV latency studies. Cells. 2021; 10: 475.

[12] Srinivasa S, Thomas TS, Feldpausch MN, Adler GK, Grinspoon SK. Coronary vasculature and myocardial structure in HIV: physiologic insights from the renin-angiotensin-aldosterone system. The Journal of Clinical Endocrinology and Metabolism. 2021; 106: 3398–3412.

[13] Hudson P, Woudberg NJ, Kamau F, Strijdom H, Frias MA, Lecour S. HIV-related cardiovascular disease: any role for high-density lipoproteins? American Journal of Physiology-Heart and Circulatory Physiology. 2020; 319: H1221–H1226.

[14] Peters M, Margevicius S, Kityo C, Mirembe G, Buggey J, Brinza E, et al. Association of kidney disease with abnormal cardiac structure and function among ugandans with hiv infection. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2021; 86: 104–109.

[15] Doria de Vasconcellos H, Post WS, Ervin A, Haberlen SA, Budoff M, Malvestutto C, et al. Associations between HIV serostatus and cardiac structure and function evaluated by 2-dimensional echocardiography in the multicenter AIDS cohort study. Journal of the American Heart Association. 2021; 10: e019709.

[16] Batta Y, King C, Cooper F, Johnson J, Haddad N, Boueri MG, et al. Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV. Frontiers in Physiology. 2023; 14: 1118653.


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