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Mini-Review

Open Access

Recent progress and controversies in the treatment of metastatic hormone-sensitive prostate cancer

  • Wei-hua Liu1,2,†
  • Jia-tao Yao1,†
  • Shi-jie Ye1
  • Peng-cheng Hu1
  • Xin Fei1
  • Qi Ma3,4,5,*,
  • Hai-chao Chen6,*,

1Health Science Center, Ningbo University, 315211 Ningbo, Zhejiang, China

2Department of Urology, Beilun People’s Hospital, 315800 Ningbo, Zhejiang, China

3Comprehensive Genitourinary Cancer Center, The First Affiliated Hospital of Ningbo University, 315010 Ningbo, Zhejiang, China

4Translational Research Laboratory for Urology, The First Affiliated Hospital of Ningbo University, 315010 Ningbo, Zhejiang, China

5Yi-Huan Genitourinary Cancer Group, 315010 Ningbo, Zhejiang, China

6Department of Urology, The First Affiliated Hospital of Ningbo University, 315010 Ningbo, Zhejiang, China

DOI: 10.22514/jomh.2024.083 Vol.20,Issue 6,June 2024 pp.1-7

Submitted: 18 October 2023 Accepted: 27 November 2023

Published: 30 June 2024

*Corresponding Author(s): Qi Ma E-mail: fyymaqi@nbu.edu.cn
*Corresponding Author(s): Hai-chao Chen E-mail: fychenhaichao@nbu.edu.cn

† These authors contributed equally.

Abstract

Androgen deprivation therapy (ADT) has long been the only treatment for metastatic hormone-sensitive prostate cancer (mHSPC). In recent years, with the use of docetaxel chemotherapy and the emergence of various novel hormone therapy drugs, such as Abiraterone, Enzalutamide, Apalutamide, Darolutamide, and Rezvilutamide, the treatment strategies for mHSPC have been greatly changed. Furthermore, local treatment has been added to the treatment of low tumor burden mHSPC and triple therapy has been regarded as an important treatment choice for high tumor burden mHSPC. The survival rate of mHSPC patients has increased significantly and the quality of life also improved with these new treatment strategies. This article reviews the latest advances and controversies in the current treatment of mHSPC. Ongoing clinical trials are introduced and further directions are also discussed in this mini-review.


Keywords

Metastatic hormone-sensitive prostate cancer; Novel hormone therapy; Androgen deprivation therapy; Triple therapy; Combination therapy; Prostate cancer


Cite and Share

Wei-hua Liu,Jia-tao Yao,Shi-jie Ye,Peng-cheng Hu,Xin Fei,Qi Ma,Hai-chao Chen. Recent progress and controversies in the treatment of metastatic hormone-sensitive prostate cancer. Journal of Men's Health. 2024. 20(6);1-7.

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