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Original Research

Open Access

The relationship between serum adropin levels and erectile dysfunction

  • Ercument Keskin1,*,
  • Ozgur Ekici2
  • Abdullah Erdogan2
  • Aliseydi Bozkurt1
  • Murat Sambel3
  • Mehmet Karabakan4
  • Cuma Mertoglu5,6

1Department of Urology, Faculty of Medicine, Erzincan Binali Yıldırım University, 24002 Erzincan, Turkey

2Department of Urology, Bursa City Hospital, 16100 Bursa, Turkey

3Department of Urology, Antalya Training and Research Hospital, 07000 Antalya, Turkey

4Department of Urology, Toros State Hospital, 33010 Mersin, Turkey

5Department of Biochemistry, Faculty of Medicine İnönü University, 44050 Malatya, Turkey

6Department of Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, 24002 Erzincan, Turkey

DOI: 10.22514/jomh.2024.091 Vol.20,Issue 6,June 2024 pp.58-63

Submitted: 04 February 2024 Accepted: 27 March 2024

Published: 30 June 2024

*Corresponding Author(s): Ercument Keskin E-mail:


Erectile dysfunction (ED) is associated with endothelial damage, especially atheroscle-rosis. The search for biomarkers that can predict ED still continues. Adropin is known to affect nitric oxide (NO) bioavailability and energy homeostasis. In our study, we have aimed to investigate the relationship between serum adropin levels and ED. Male patients with and without ED between 40–60 years of age, who presented to the outpatient clinics of urology between November 2019–February 2020, were prospectively included in the study. Biochemical values measured at the time of admission to the outpatient clinic. According to the International Index of Erectile Function-5 (IIEF-5) scores which range between 5 and 25 points, patients with a score ≤21 were considered to have ED. The patients were divided into two groups: as ED and non-ED control groups. Laboratory values obtained at admission to outpatient clinics of urology were compared between groups. Patients with (n: 40), and without (n: 40) ED were included in the study. The mean age (50.2 ± 5.7 years), average body mass index (BMI) (29.7 ± 2.5 kg/m2), IIEF score (15.8 ± 6 pts), serum adropin (584.8 ± 172 pg/mL), and total testosterone (396.4 ± 91.7 ng/dL) levels were recorded. Serum adropin and testosterone levels were statistically significantly higher in the non-ED group than in the ED group (712.3 ± 222 pg/mL vs. 511.1 ± 145 pg/mL, p < 0.001 and 420.5 ± 56 ng/dL vs. 374.3 ± 98 ng/dL, respectively p = 0.032). Whereas fasting blood glucose (FBG) values were found to be statistically significantly higher in the ED group (100.2 ± 14 mg/dL vs. 143.8 ± 78 mg/dL, p = 0.001). According to the results of our study, serum levels of adropin which improves endothelial functions were comparatively lower in ED patients, as expected.


Adropin; Biomarkers; Erectile dysfunction; Total testosterone

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Ercument Keskin,Ozgur Ekici,Abdullah Erdogan,Aliseydi Bozkurt,Murat Sambel,Mehmet Karabakan,Cuma Mertoglu. The relationship between serum adropin levels and erectile dysfunction. Journal of Men's Health. 2024. 20(6);58-63.


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