A study on the differences and influencing factors of sleep quality in epilepsy patients of different genders

This study aims to evaluate and analyze the differences in sleep quality among epilepsy patients of different genders to provide a reference for determining the influencing factors of sleep quality based on logistic multiple regression analysis. A retrospective analysis was conducted on the clinical data of 220 epilepsy patients admitted to our hospital from May 2022 to November 2023. The patients were divided into low-quality and high-quality sleep groups. Data were obtained using a general information questionnaire survey and the Pittsburgh Sleep Quality Index (PSQI). The average PSQI score for male patients was 12.89 ± 3.13, while for female patients, it was 9.26 ± 2.60. The PSQI score for male patients was significantly higher than that for female patients (p < 0.05). Moreover, the influencing factors for sleep quality in epilepsy patients included gender, annual income, medical insurance, frequency of epilepsy onset and medication use. Male epilepsy patients suffer from poorer sleep quality compared to female patients. Factors such as gender, annual income, medical insurance, seizure frequency and medication use significantly affect sleep quality in epilepsy patients. It could be recommended that patients adhere to medical advice for managing epilepsy and that healthcare authorities enhance awareness and policy support to reduce seizures and improve patients’ quality of life.

Gender; Epilepsy; Sleep quality; Differences; Influence factor

[1] Zambrano Chaves JM, Lenchik L, Gallegos IO, Blankemeier L, Liang T, Rubin DL, et al. Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study. EBioMedicine. 2024; 103: 105116.

[2] Roliz AH, Kothare S. The interaction between sleep and epilepsy. Current Neurology and Neuroscience Reports. 2022; 22: 551–563.

[3] Ozdemir FMA, Celik H. Evaluation of sleep habits and their relationship with quality of life in children with epilepsy. Pediatric Neurology. 2024; 155: 114–119.

[4] Cristovao Ferreira A, Moniz Dionisio J, Ferreira R, Coelho J. Epileptic seizure or parasomnia? From knowledge to recognition. Sleep-related hypermotor epilepsy. Annals of Pediatrics. 2024; 100: 386–387.

[5] Crawford J, McFarlane C, Datta AN. Original research: clinical significance of a unique pediatric EEG configuration: Bi-frontal spikes with simultaneous Bi-occipital positivity. To be published in Clinical EEG and Neuroscience. 2024. [Preprint].

[6] Parnia S, Patel J, Bloom BM, Kulstad E, Deakin CD, Spiegel R. Recalled experience of death: disinhibition not degeneration in relation to death facilitates inner states of lucid hyperconsciousness with novel cognitive insights. Resuscitation. 2024; 199: 110205.

[7] Jiang YL, Xia L, Zhao JJ, Zhou HM, Mi D, Wang X, et al. Mice harboring the T316N variant in the GABAARg2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway. Experimental Neurology. 2024; 376: 114775.

[8] Avarisli A, Varoglu AO, Keskin H, Erman H. HPA axis function in patients with right and left focal lateralized epilepsy. To be published in Neuro Enocrinology Letters. 2024. [Preprint].

[9] AlMail A, Jamjoom A, Pan A, Feng MY, Chau V, D’Gama AM, et al. Consensus reporting guidelines to address gaps in descriptions of ultra-rare genetic conditions. NPJ Genomic Medicine. 2024; 9: 27.

[10] Nobili L, Frauscher B, Eriksson S, Gibbs SA, Halasz P, Lambert I, et al. Sleep and epilepsy: a snapshot of knowledge and future research lines. Journal of Sleep Research. 2022; 31: e13622.

[11] Moore JL, Carvalho DZ, St Louis EK, Bazil C. Sleep and epilepsy: a focused review of pathophysiology, clinical syndromes, co-morbidities, and therapy. Neurotherapeutics. 2021; 18: 170–180.

[12] Grigg-Damberger MM, Foldvary-Schaefer N. Sleep and epilepsy: practical implications. Neurologic Clinics. 2022; 40: 769–783.

[13] Mierlo PV, Braakman H, Vandenbussche N, Schelhaas HJ, Pillen S. Epilepsy and sleep in the ATR-X syndrome. Neuropediatrics. 2022; 53: 109–114.

[14] Wu T, Avidan AY, Engel J Jr. Sleep and epilepsy, clinical spectrum and updated review. Sleep Medicine Clinics. 2021; 16: 389–408.

[15] Peng W, Ding J, Wang X. The management and alternative therapies for comorbid sleep disorders in epilepsy. Current Neuropharmacology. 2021; 19: 1264–1272.

[16] Hanke JM, Schindler KA, Seiler A. On the relationships between epilepsy, sleep, and Alzheimer’s disease: a narrative review. Epilepsy & Behavior. 2022; 129: 108609.

[17] Sethi NK. The Relationship between epilepsy, obstructive sleep apnea, and treatment outcome. Sleep Medicine Clinics. 2022; 17: 639–645.

[18] Pace A, Watkins L, Fiott D, Bassett P, Laugharne R, James C, et al. Identifying co-morbidities and risk in people with epilepsy: the Maltese experience. Epilepsy & Behavior. 2024; 155: 109795.

[19] Jaseja H, Goyal M, Mishra P. Drug-resistant epilepsy and obstructive sleep apnea: exploring a link between the two. World Neurosurgery. 2021; 146: 210–214.

[20] Tavakol S, Kebets V, Royer J, Li Q, Auer H, DeKraker J, et al. Differential relational memory impairment in temporal lobe epilepsy. Epilepsy & Behavior. 2024; 155: 109722.