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Original Research

Open Access

A comparative study of tumor markers and dynamic contrast-enhanced CT and their combined evaluation in the diagnosis of renal cancer patients

  • Xiaofeng Wang1
  • Peipei He1
  • Minghui Yan1,*,

1Medical Imaging Center, Ningbo Yinzhou No.2 Hospital, 315192 Ningbo, Zhejiang, China

DOI: 10.22514/jomh.2024.156 Vol.20,Issue 9,September 2024 pp.111-117

Submitted: 27 May 2024 Accepted: 10 July 2024

Published: 30 September 2024

*Corresponding Author(s): Minghui Yan E-mail: lh_jiao0221@163.com

Abstract

The objectives of this study were to investigate the diagnostic efficacy of dynamic contrast-enhanced Computed Tomography (CT) and tumor markers and their combined evaluation in renal cancer patients. A total of eighty male patients with solid renal lesions were selected from our hospital and categorized into two groups based on pathological examination findings: renal cancer group and benign lesion group. A comparison was made between the findings of dynamic contrast-enhanced CT and tumor markers and the diagnostic efficacy of either mono or combined evaluation were compared. Receiver operating characteristic curves were plotted to better analyze and compare different diagnostic techniques. The serum concentrations of carcinoembryonic antigen (CEA), Cytokeratin 19 fragment (CYFRA21-1), midkine (MK) and matrix metalloproteinase 9 (MMP-9) in renal cancer patients were significantly higher than those with benign lesions (p < 0.05). The Receiver Operating Characteristic (ROC) curve analysis demonstrated that the combination of dynamic contrast-enhanced CT and tumor markers had the highest area under the curve. This difference was statistically significant (p < 0.05). The analysis of the overall model quality results revealed that the model values for both single and combination indicators exceeded 0.5, with the combined indicators having the highest value of (0.84). The diagnostic efficacy of dynamic contrast-enhanced CT combined with tumor markers for renal cancer is significantly higher than either the dynamic contrast-enhanced CT or tumor markers alone. The combination of dynamic contrast-enhanced CT and tumor markers has a significant therapeutic benefit in diagnosing renal cancer. We envisage that, this approach can offer valuable guidance for the clinical diagnosis and treatment of renal cancer.


Keywords

Dynamic contrast-enhanced CT; Tumor markers; Combined examination; Renal cancer; Diagnostic efficacy


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Xiaofeng Wang,Peipei He,Minghui Yan. A comparative study of tumor markers and dynamic contrast-enhanced CT and their combined evaluation in the diagnosis of renal cancer patients. Journal of Men's Health. 2024. 20(9);111-117.

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