Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Clinical efficacy of CO2 laser therapy combined with photodynamic therapy in male patients with condyloma acuminatum
1Department of Dermatology, Qingyuan County People’s Hospital, 323800 Lishui, Zhejiang, China
2Department of Dermatology, Lishui Central Hospital, 323000 Lishui, Zhejiang, China
DOI: 10.22514/jomh.2024.157 Vol.20,Issue 9,September 2024 pp.131-137
Submitted: 28 June 2024 Accepted: 28 August 2024
Published: 30 September 2024
*Corresponding Author(s): Shaofang Wu E-mail: wushaofang4050701@126.com
This study investigated the clinical efficacy of Carbon dioxide (CO2) laser therapy combined with photodynamic therapy in male patients with condyloma acuminatum. A retrospective analysis was conducted on 120 male patients with genital warts treated at our hospital. Based on different treatment methods, they were divided into a control group and an observation group, each consisting of 60 cases. The control group received CO2 laser treatment, while the observation group received photodynamic therapy and CO2 laser treatment. Levels of lymphocyte chemotactic factor (LTN), human beta-defensin-2 (HBD-2), B-cell lymphoma-2 (Bcl-2), interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-α), T lymphocytes (CD3+), inducible T cells (CD4+), suppressive T cells (CD8+), Male Sexual Function Index (MSFI) scores, Chinese version of the Genital Warts Quality of Life Scale (CECA10) scores, incidence of adverse reactions, recurrence rate, and total treatment effectiveness were compared between groups. After therapy, both groups showed reduced levels of Bcl-2 and TNF-α, but increased levels of IL-12. The observation group had significantly lower Bcl-2, TNF-α and greater IL-12 levels than the control group (p < 0.05). After therapy, both groups showed increased levels of CD3+ and CD4+ but lower levels of CD8+ than before treatment. The observation group had significantly greater CD3+ and CD4+ levels, but lower CD8+ levels than the control group (p < 0.05). The observation group had significantly higher CD3+ and CD4+ levels and lower CD8+ levels compared to the control group (p < 0.05). The incidence of complications in the observation group was significantly lower than in the control group (p < 0.05). CO2 laser therapy combined with 5-aminolevulinic acid photodynamic therapy demonstrates efficacy in treating male genital warts. This therapy can significantly reduce inflammation, improve immune function, and help improve quality-of-life.
CO2 laser therapy; Photodynamic therapy; Male; condyloma acuminatum; Clinical efficacy
Yinghua Wu,Lijuan Liu,Chenlu Zhu,Hui Lin,Shaofang Wu. Clinical efficacy of CO2 laser therapy combined with photodynamic therapy in male patients with condyloma acuminatum. Journal of Men's Health. 2024. 20(9);131-137.
[1] Purzycka-Bohdan D, Nowicki RJ, Herms F, Casanova JL, Fouéré S, Béziat V. The pathogenesis of giant condyloma acuminatum (buschke-lowenstein tumor): an overview. International Journal of Molecular Sciences. 2022; 23: 4547.
[2] Jin G, Liu Y, Wang S, Zhang X, Wang S, Zhou K, et al. Efficacy and safety of Chinese patent medicine paiteling in condyloma acuminatum: a systematic review and meta-analysis. Journal of Ethnopharmacology. 2024; 318: 116894.
[3] Wu L, Wang W, Zhang J, Wu X, Chen Y, Gu X, et al. Detection of five types of HPV genotypes causing anogenital warts (condyloma acuminatum) using PCR-Tm Analysis technology. Frontiers in Microbiology. 2022; 13: 857410.
[4] Zhan M, Tong Z, Chen S, Miao Y, Yang Y. Establishing a prediction model for recurrence of condyloma acuminatum. European Journal of Medical Research. 2022; 27: 183.
[5] WHO. Guidelines for the management of symptomatic sexually transmitted infections. World Health Organization: Geneva. D2021.
[6] Chen G, Gao L, Zheng P, Liu Y, Li P, Liu H. Prevalence and genetype distribution of human papillomavirus in women with condyloma acuminatum in Henan province, central China. Infection and Drug Resistance. 2023; 16: 4919–4928.
[7] Fan Z, Wang S, Xu C, Yang J, Cui B. Mechanisms of action of Fu Fang Gang Liu liquid in treating condyloma acuminatum by network pharmacology and experimental validation. BMC Complementary Medicine and Therapies. 2023; 23: 128.
[8] Wang MF, Lin L, Li LF. Efficacy and safety of giant condyloma acuminatum with monotherapy of topical traditional Chinese medicine: report of eight cases. Infection and Drug Resistance. 2021; 4: 1375–1379.
[9] Dai Y, Yu L, Wang Y, Gao M, Wang P. Case report: a case of hailey–hailey disease mimicking condyloma acuminatum and a novel splice-site mutation of ATP2C1 gene. Frontiers in Genetics. 2021; 12: 777630.
[10] D’Erme AM, Fidanzi C, Janowska A, Dini V, Romanelli M, Zucchi V, et al. Umbilical giant condyloma acuminatum. Sexually Transmitted Infections. 2022; 98: 460.
[11] Wang HF, An RZ, Ma L, Gao XH. Recurrent condyloma acuminatum after cryotherapy plus photodynamic therapy successfully treated by local hyperthermia: a case report. Dermatologic Therapy. 2022; 35: e15771.
[12] Wei ZD, Sun YZ, Qi RQ, Jin MZ, Gao XH. Giant condyloma acuminatum treated successfully with mild local hyperthermia: two case reports. Acta Dermato-Venereologica. 2021; 101: adv00391.
[13] Chi CC, Jing J. Extragenital giant condyloma acuminatum in a hepatocellular carcinoma patient treated with lenvatinib plus PD-1 inhibitor. International Journal of Dermatology. 2023; 62: 1423–1424.
[14] Jin S, Liu L, Li R, Zhou X, Wang Z, Luan C, et al. A rare case of self-healing giant condyloma acuminatum. Dermatologic Therapy. 2022; 35: e15189.
[15] Long SQ, Li CQ. A case of giant condyloma acuminatum (Buschke-Lowenstein tumor) successfully treated with acitretin. Dermatologic Therapy. 2021; 34: e14905.
[16] Yin G, Zhang Y, Liu J, Wang P, Li X. Successful application of aminolevulinic acid/photodynamic therapy in the treatment of condyloma acuminatum in a young child. Photodiagnosis and Photodynamic Therapy. 2022; 38: 102746.
[17] Liu L, Wei G, Xu Q, Zhang C, Zhang C, Meng L, et al. Photodynamic therapy in the treatment of perianal condyloma acuminatum with hemorrhoids: a report of two cases. Photodiagnosis and Photodynamic Therapy. 2022; 37: 102644.
[18] Langham AR, Gabler T, Bebington C, Brisighelli G, Westgarth-Taylor C. Paediatric Anogenital Condylomata Acuminata: an assessment of patient characteristics and the need for surgical intervention. Journal of Pediatric Surgery. 2022; 57: 715–718.
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