Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Metabolic markers in male infertility: a pilot study
1Department of Reproductive Biology, All India Institute of Medical Sciences, 110029 New Delhi, India
DOI: 10.22514/jomh.2024.158 Vol.20,Issue 9,September 2024 pp.138-145
Submitted: 11 April 2024 Accepted: 28 June 2024
Published: 30 September 2024
*Corresponding Author(s): Mona Sharma E-mail: monasharma@aiims.edu
Male infertility is an emerging health problem and there is an urgent need to search for therapeutic options. Altered metabolic states such as obesity and metabolic syndrome have been linked with male infertility. Therefore, searching for metabolic biomarkers is vital. Present work aimed to study metabolic alterations in infertile males. The seminal levels of L-Carnitine (LC), Kisspeptin (Kiss1) and Ghrelin (GHRL) were evaluated in 14 infertile and 10 fertile males. Baseline semen analysis was performed for both cases and controls. The levels of LC and Kiss1 were found to be lower in infertile patients as compared to fertile controls and the difference was found to be statistically significant. There was no significant difference observed in GHRL levels between patients and controls. The study presents a preliminary data where LC and Kiss1 levels could possibly studied further for their association with male infertility. But to confirm their association with pathogenesis of male infertility, future studies need to be conducted in larger cohorts.
L-carnitine (LC); Assisted reproductive technology; Male infertility; Intra cytoplasmic sperm injection (ICSI); Ghrelin (GHRL); Kisspeptin (Kiss1)
Kajal Sihag,Ashutosh Halder,Mona Sharma. Metabolic markers in male infertility: a pilot study. Journal of Men's Health. 2024. 20(9);138-145.
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