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Original Research

Open Access

Prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancer

  • Jianming Lu1,†
  • Yunze Fang2,†
  • Jiexin Luo2,†
  • Runxin Zhou3
  • Le Zhang4
  • Chao Cai5
  • Zhengguo Cao2,*,
  • Rujun Mo2,3,6,*,

1Department of Andrology, Guangzhou First People’s Hospital, Guangzhou Medical University, 510180 Guangzhou, Guangdong, China

2Department of Urology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), 523059 Dongguan, Guangdong, China

3Graduate School, Guangdong Medical University, 524002 Zhanjiang, Guangdong, China

4Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA

5Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou Institute of Urology, 510230 Guangzhou, Guangdong, China

6Department of Urology, Dongguan People’s Hospital, Guangdong Medical University, 523059 Dongguan, Guangdong, China

DOI: 10.22514/jomh.2024.194 Vol.20,Issue 11,November 2024 pp.136-146

Submitted: 12 June 2024 Accepted: 18 July 2024

Published: 30 November 2024

*Corresponding Author(s): Zhengguo Cao E-mail: zgcao2023@smu.edu.cn
*Corresponding Author(s): Rujun Mo E-mail: rmo@smu.edu.cn

† These authors contributed equally.

Abstract

Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) has been implicated in some tumor types, but its role in primary prostate cancer (PCa) remains unexplored. This study investigates the prognostic significance of PITPNC1 in PCa. RNA sequencing (RNA-seq), mutation data and clinical information on PCa cohorts were retrieved from the The Cancer Genome Atlas Program (TCGA) and Gene Expression Omnibus (GEO) databases. Data analysis revealed that PITPNC1 expression was significantly lower in PCa tissues compared to benign tissues, and this reduced expression correlated with earlier biochemical recurrence and decreased overall survival. Functional enrichment analysis indicated that PITPNC1 activates pathways related to cell adhesion and immune receptor signaling while inhibiting RNA metabolism pathways. Additionally, high Tumor Protein P53 (TP53) mutation frequency was observed in the low PITPNC1 expression group. In immunotherapy cohorts, lower PITPNC1 expression was associated with poorer outcomes. Furthermore, Rucaparib was identified as a potential therapeutic agent for patients with low PITPNC1 expression. Collectively, we identified PITPNC1 as a promising prognostic marker in PCa. Its expression levels can predict immunotherapy responses, and it holds potential as a target for precision therapies.


Keywords

Prostate cancer; PITPNC1; Biochemical recurrence; TP53; Immunotherapy


Cite and Share

Jianming Lu,Yunze Fang,Jiexin Luo,Runxin Zhou,Le Zhang,Chao Cai,Zhengguo Cao,Rujun Mo. Prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancer. Journal of Men's Health. 2024. 20(11);136-146.

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