Neuroendocrine cancer of the prostate. Two case reports
1Department of Oncoradiology, Petz Aladár Hospital, 9024 Győr, Hungary
2Department of Pathology, Petz Aladár Hospital, 9024 Győr, Hungary
3Department of Urology, Petz Aladár Hospital, 9024 Győr, Hungary
DOI: 10.31083/j.jomh1803065 Vol.18,Issue 3,March 2022 pp.1-4
Submitted: 31 August 2021 Accepted: 26 October 2021
Published: 31 March 2022
Background: Neuroendocrine cancer of the prostate can present in diverse clinical pictures, potentially hampering the diagnosis and probably leading to underdiagnosis. Methods: Two cases are presented corresponding respectively to two forms of the disease: de novo neuroendocrine cancer and dedifferenciation of an adenocarcinoma of the prostate to neuroendocrine cancer under long term luteinising hormone releasing hormone (LHRH) agonist treatment. Results: Suspicion of neuroendocrine cancer may be raised in prostate cancer patients presenting either clinical or radiological metastatic progression without prostate specific antigen (PSA) rise, or relatively extended metastatic disease right at diagnosis associated to relatively low PSA, yet any non-pulmonary visceral metastases. Neuroendocrine cancer of the prostate can also turn out to be the origin of an adenocarcinoma of unknown primary. Conclusion: In case these considerations are respected the risk of missing the correct diagnosis of a neuroendocrine cancer of the prostate may be minimised.
Neuroendocrine cancer; Prostate cancer; Serum marker; Synaptophysin; NSE
Tamás Kullmann,Szigeti András,Kránitz Noémi,Szepesváry Zsolt. Neuroendocrine cancer of the prostate. Two case reports. Journal of Men's Health. 2022. 18(3);1-4.
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