Article Data

  • Views 896
  • Dowloads 150

Case Report

Open Access Special Issue

Prostatic signet-ring adenocarcinoma: A case report

  • Ali Al Khader1,2,*,
  • Esra Nsour2
  • Taleb Al Edwan3

1Department of Pathology and Forensic Medicine, Faculty of Medicine, Al-Balqa Applied University, 19117 Al-Salt, Jordan

2Department of Pathology, Al Hussein Salt Hospital, Ministry of Health, 19117 Al-Salt, Jordan

3Department of Urology, Al-Hussein Salt Hospital, Ministry of Health, 19117 Al-Salt, Jordan

DOI: 10.31083/j.jomh1804090 Vol.18,Issue 4,April 2022 pp.1-3

Submitted: 26 August 2021 Accepted: 11 October 2021

Published: 30 April 2022

(This article belongs to the Special Issue Therapy and prognosis of metastatic prostate cancer)

*Corresponding Author(s): Ali Al Khader E-mail:


Background: Prostatic signet-ring adenocarcinoma is a rare histological variant of prostate cancer. The tumor is characterized by an aggressive clinical course. Methods: Herein we present the case of a 78-year-old man with obstructive urinary symptoms and elevated serum prostate specific antigen. Transurethral resection of the prostate was performed. Results: Histologically, a tumor that was mainly composed of signet ring cells was identified. The tumor cells were positive for alcian blue special stain. Another Gleason 4 adenocarcinoma component was identified. The patient received hormonal therapy. A favorable response was documented at 8 months of follow up. Conclusions: Ruling out another primary site of origin, such as the gastrointestinal tract, is mandatory, and a more aggressive management plan should be put in mind.


Carcinoma; Prostate; Signet ring cell

Cite and Share

Ali Al Khader,Esra Nsour,Taleb Al Edwan. Prostatic signet-ring adenocarcinoma: A case report. Journal of Men's Health. 2022. 18(4);1-3.


[1] Torbenson M, Dhir R, Nangia A, Becich MJ, Kapadia SB. Pro-static carcinoma with signet ring cells: a clinicopathologic and immunohistochemical analysis of 12 cases, with review of the literature. Modern Pathology. 1998; 11: 552–559.

[2] Kuroda N, Yamasaki I, Nakayama H, Tamura K, Yamamoto Y, Miyazaki E, et al. Prostatic signet-ring cell carcinoma: case re-port and literature review. Pathology International. 1999; 49: 457–461.

[3] Smith C, Feddersen RM, Dressler L, McConnell T, Milroy T, Smith AY. Signet ring cell adenocarcinoma of prostate. Urology. 1994; 43: 397–400.

[4] Celik O, Budak S, Ekin G, Akarken I, Ilbey YO. A case with primary signet ring cell adenocarcinoma of the prostate and re-view of the literature. Archivio Italiano di Urologia e Androlo-gia. 2014; 86: 148–149.

[5] Sungur M, Şentürk AB, Çalışkan S, Gürel A. Primary signet cell carcinoma of the prostate: a case report. Memo-Magazine of Eu-ropean Medical Oncology. 2017; 10: 115–117.

[6] Kim SW, Kim W, Cho Y, Kim T, Woo I, Sohn DW. Primary signet ring cell carcinoma of the prostate treated by radical cystoprostatectomy and chemoradiotherapy. Canadian Urolog-ical Association Journal. 2019; 10: E204–E206.

[7] Pinta DLC, Martin M. A case with primary signet ring cell ade-nocarcinoma of the prostate and review of the literature. Journal of Cancer Prevention & Current Research. 2017; 7: 0025.

[8] Gök A, Tuygun C, Akmansu M, Uslu AA, Kartal IG, Sandikçi F, et al. Primary signet ring cell carcinoma of the prostate: a rare case report. Journal of Clinical Medicine. 2019; 7: 218.

[9] Kwon W, Oh TH, Ahn SH, Lee JW, Park SC. Primary signet ring cell carcinoma of the prostate. Canadian Urological Association Journal. 2013; 7: E768–E771.

[10] Fujita K, Sugao H, Gotoh T, Yokomizo S, Itoh Y. Primary signet ring cell carcinoma of the prostate: report and review of 42 cases. International Journal of Urology. 2004; 11: 178–181.

[11] Singh P, Albertson D, Pal SK, Agarwal N. Mucinous, Signet Ring, Ductal, and Sarcomatoid Variants of Prostate Cancer. Rare Genitourinary Tumors. 2016; 65: 205–218.

[12] Guerin D, Hasan N, Keen CE. Signet ring cell differentia-tion in adenocarcinoma of the prostate: a study of five cases. Histopathology. 1993; 22: 367–371.

[13] Alguacil-Garcia A. Artifactual changes mimicking signet ring cell carcinoma in transurethral prostatectomy specimens. The American Journal of Surgical Pathology. 1986; 10: 795–800.

[14] Skodras G, Wang J, Kragel PJ. Primary prostatic signet-ring cell carcinoma. Urology. 1993; 42: 338–342.

[15] Warner JN, Nakamura LY, Pacelli A, Humphreys MR, Castle EP. Primary signet ring cell carcinoma of the prostate. Mayo Clinic Proceedings. 2011; 85: 1130–1136.

[16] Lilleby W, Axcrona K, Alfsen GC, Urnes T, Hole KH. Diag-nosis and treatment of primary signet-ring cell carcinoma of the prostate. Acta Oncologica. 2008; 46: 1195–1197.

[17] Akagashi K, Tanda H, Kato S, Ohnishi S, Nakajima H, Nanbu A, et al. Signet-ring cell carcinoma of the prostate effectively treated with maximal androgen blockade. International Journal of Urology. 2004; 10: 456–458.

[18] Roldán AM, Núñez NF, Grande E, García A, Antón-Aparicio LM. A Primary Signet Ring Cell Carcinoma of the Prostate with Bone Metastasis with Impressive Response to FOLFOX and Ce-tuximab. Clinical Genitourinary Cancer. 2012; 10: 199–201.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Directory of Open Access Journals (DOAJ) DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.

SCImago The SCImago Journal & Country Rank is a publicly available portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database (Elsevier B.V.)

Publication Forum - JUFO (Federation of Finnish Learned Societies) Publication Forum is a classification of publication channels created by the Finnish scientific community to support the quality assessment of academic research.

Scopus: CiteScore 0.9 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Norwegian Register for Scientific Journals, Series and Publishers Search for publication channels (journals, series and publishers) in the Norwegian Register for Scientific Journals, Series and Publishers to see if they are considered as scientific. (

Submission Turnaround Time