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Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions(PSSD): Clinical Experience with a Multimodal Approach

  • Yacov Reisman1,*,
  • Tommaso B. Jannini2
  • Emmanuele A. Jannini3

1Department of Sexual Medicine, Flare-Health, 1183DJ Amstelveen, The Netherlands

2School of Psychiatry, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy

3Chair of Endocrinology and Medical Sexology (ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy

DOI: 10.31083/j.jomh1808165 Vol.18,Issue 8,August 2022 pp.1-8

Submitted: 28 December 2021 Accepted: 18 March 2022

Published: 31 August 2022

*Corresponding Author(s): Yacov Reisman E-mail:


Background: Post-SSRI sexual dysfunction (PSSD) is a set of heterogeneous sexual disorders, that may arise during the administration of antidepressant Selective Serotonin Reuptake Inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitor (SNRIs) and may persist after their discontinuation. PSSD is commonly associated with sexual problems with marked distress and poor quality of life. To date, however, no effective treatment is available. The study describes the clinical experience with a newly introduced systems sexology approach involving bio-psycho-social interventions. Methods: In this study we retrospectively analyzed (from July 2019 to July 2020) twelve PSSD male patients (mean age 31.3 ± 6.21 years old) treated according to a recently introduced approach involving system sexology and bio-psycho-social interventions. The protocol was based on a combination of lifestyle changes, nutritional supplementation, pharmacological and behavioral interventions. Results: 12 patients with high probability of PSSD were selected. Patients reported a significant improvement in all International Index of Erectile Function-15 (IIEF) domains and Orgasmometer scores from the baseline at 6 months of follow-up. Conclusions: This study described for the first time a feasible and handy treatment procedure for PSSD, framework to improve patients complains, sexual function and satisfaction, and quality of life. Future randomized, placebo-controlled clinical studies with bigger cohorts will be needed in order to better assess this efficacy and confirm our results.


PSSD; multimodal approach; SSRI

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Yacov Reisman,Tommaso B. Jannini,Emmanuele A. Jannini. Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions(PSSD): Clinical Experience with a Multimodal Approach. Journal of Men's Health. 2022. 18(8);1-8.


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