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Open Access Special Issue

Presentation, Management, and Outcomes of Penile Fractures

  • Meher Pandher1,*,
  • Gabriel Fernandez Pedrosa1
  • Amjad Alwaal1

1Division of Urology, New Jersey Medical School, Newark, NJ 07103, USA

DOI: 10.31083/j.jomh1811215 Vol.18,Issue 11,November 2022 pp.1-8

Published: 30 November 2022

(This article belongs to the Special Issue Selected Papers in Sexual Medicine and Men’s Health)

*Corresponding Author(s): Meher Pandher E-mail: mp1257@njms.rutgers.edu

Abstract

Background: Penile fractures are due to a traumatic rupture of the penile tunica albuginea of the corpus cavernosum and may result from numerous etiologies. The purpose of our review is to describe the etiology, management, and outcomes of penile fractures. Methods: A literature review was performed. Results: The diagnosis of penile fractures is usually made clinically but can also be made with the assistance of ultrasound or MRI (magnetic resonance imaging) imaging when unclear. Cystoscopy should be performed when urethral involvement is suspected. Surgical management should be initiated promptly after the diagnosis, and within 24 hours of presentation. Surgical management can include the subcoronal or penoscrotal approach, although the penoscrotal approach is preferred when imaging confirms the location of the injury to be ventral and proximal, due to the reduced morbidity of this technique. Complications following penile fractures include erectile dysfunction, penile curvature, and voiding symptoms, but the incidence of complications is reduced if surgical intervention is performed promptly after fracture presentation. A rare cause of penile fractures is collagenase clostridium histolyticum injection, and these cases should predominantly be managed conservatively. Conclusions: Penile fractures can present in various ways and must be managed surgically and promptly after the diagnosis is made.

Keywords

penile fractures; rupture of corpus cavernosum; collagenase clostridium histolyticum; immediate vs. delayed management of penile fracture

Cite and Share

Meher Pandher,Gabriel Fernandez Pedrosa,Amjad Alwaal. Presentation, Management, and Outcomes of Penile Fractures. Journal of Men's Health. 2022. 18(11);1-8.

References

[1] Diaz KC, Cronovich H. Penis Fracture. In StatPearls. StatPearls Publishing: Treasure Island (FL). 2022.

[2] Rodriguez D, Li K, Apoj M, Munarriz R. Epidemiology of Pe-nile Fractures in United States Emergency Departments: Ac-cess to Care Disparities may Lead to Suboptimal Outcomes. The Journal of Sexual Medicine. 2019; 16: 248–256.

[3] Mirzazadeh M, Fallahkarkan M, Hosseini J. Penile fracture epi-demiology, diagnosis and management in Iran: a narrative re-view. Translational Andrology and Urology. 2017; 6: 158–166.

[4] Özorak A, Hoşcan MB, Oksay T, Güzel A, Koşar A. Manage-ment and outcomes of penile fracture: 10 years’ experience from a tertiary care center. International Urology and Nephrology. 2014; 46: 519–522.

[5] Hsu G, Brock G, Martínez-Piñeiro L, von Heyden B, Lue TF, Tanagho EA. Anatomy and Strength of the Tunica Albuginea: its Relevance to Penile Prosthesis Extrusion. Journal of Urology. 1994; 151: 1205–1208.

[6] Simms A, Baradaran N, Lue TF, Breyer BN. Penile Fractures: Evaluation and Management. Urologic Clinics of North Amer-ica. 2021; 48: 557–563.

[7] Amer T, Wilson R, Chlosta P, AlBuheissi S, Qazi H, Fraser M, et al. Penile Fracture: a Meta-Analysis. Urologia Internationalis. 2016; 96: 315–329.

[8] Zargooshi J. Sexual Function and Tunica Albuginea Wound Healing Following Penile Fracture: an 18-year Follow-up Study of 352 Patients from Kermanshah, Iran. The Journal of Sexual Medicine. 2009; 6: 1141–1150.

[9] Al-Shaiji TF, Amann J, Brock GB. Fractured penis: diagno-sis and management. The Journal of Sexual Medicine. 2009; 6: 3231–3241.

[10] Peradejordi Font MR, Mercader Barrull C, López Martínez JM, Corral Molina JM, García Cruz E, Alcaraz Asensio A, et al. Con-sequences of penile fracture: Complications and long-term func-tional outcomes. Actas Urologicas Espanolas. 2022; 46: 178–183.

[11] Falcone M, Garaffa G, Castiglione F, Ralph DJ. Current Man-agement of Penile Fracture: an up-to-Date Systematic Review. Sexual Medicine Reviews. 2018; 6: 253–260.

[12] Agarwal MM, Singh SK, Sharma DK, Ranjan P, Kumar S, Chandramohan V, et al. Fracture of the penis: a radiological or clinical diagnosis? A case series and literature review. The Canadian Journal of Urology. 2009; 16: 4568–4575.

[13] Shimpi RK, Patel PJ, Bhondave ST. Penile fracture: Institutional experience of 14 cases. Urology Annals. 2021; 13: 351–355.

[14] McEleny K, Ramsden P, Pickard R. Penile fracture. Nature Clin-ical Practice Urology. 2006; 3: 170–174.

[15] Ory J, Bailly G. Management of penile fracture. Canadian Uro-logical Association Journal. 2019;13: S72–S74.

[16] Bhoil R, Sood D. Signs, symptoms and treatment of penile frac-ture. Emergency Nurse. 2015; 23: 16–17.

[17] Feki W, Derouiche A, Belhaj K, Ouni A, Ben Mouelhi S, Ben Slama MR, et al. False penile fracture: report of 16 cases. International Journal of Impotence Research. 2007; 19: 471–473.

[18] Scott SE, Langenohl R, Crisostomo-Wynne T, Kang C. Penile Dorsal Vein Rupture Identified by Emergency Department Ultrasound. Clinical Practice and Cases in Emergency Medicine. 2021; 5: 121–122.

[19] Chahal A, Gupta S, Das C. Penile fracture.BMJ Case Reports. 2016￿bcr2016215385.

[20] Koifman L, Barros R, Júnior RAS, Cavalcanti AG, Favorito LA. Penile Fracture: Diagnosis, Treatment and Outcomes of 150 Patients. Urology. 2010; 76: 1488–1492.

[21] Zare Mehrjardi M, Darabi M, Bagheri SM, Kamali K, Bijan B. The role of ultrasound (US) and magnetic resonance imaging (MRI) in penile fracture mapping for modified surgical repair. International Urology and Nephrology. 2017; 49: 937–945.

[22] Derouiche A, Belhaj K, Hentati H, Hafsia G, Slama MRB, Chebil M. Management of penile fractures complicated by urethral rupture. International Journal of Impotence Research. 2008; 20: 111–114.

[23] Shukla AK, Bhagavan BC, Sanjay SC, Krishnappa N, Sahadev R, V S. Role of ultraosonography in grading of penile fractures. Journal of Clinical and Diagnostic Research. 2015; 9: TC01–TC03.

[24] Dell’Atti L. The role of ultrasonography in the diagnosis and management of penile trauma. Journal of Ultrasound. 2016; 19: 161–166.

[25] Cozzi D, Verrone GB, Agostini S, Bartolini M, D’Amico G, Pradella S, et al. Acute penile trauma: imaging features in the emergency setting. La Radiologia Medica. 2019; 124: 1270–1280.

[26] Metzler IS, Reed-Maldonado AB, Lue TF. Suspected penile fracture: to operate or not to operate? Translational Andrology and Urology. 2017; 6: 981–986.

[27] Bhoopathy SV, Kim LH. The value of pre-operative MRI in management of penile fractures. Urology Case Reports. 2020; 31: 101185.

[28] Saglam E, Tarhan F, Hamarat MB, Can U, Coskun A, Camur E, et al. Efficacy of magnetic resonance imaging for diagnosis of penile fracture: a controlled study. Investigative and Clinical Urology. 2017; 58: 255–260.

[29] Guler I, Ödev K, Kalkan H, Simsek C, Keskin S, Kilinç M. The value of magnetic resonance imaging in the diagnosis of penile fracture. International Braz J Urol. 2015; 41: 325–328.

[30] Esposito AA, Giannitto C, Muzzupappa C, Maccagnoni S, Gadda F, Albo G, et al. MRI of penile fracture: what should be a tailored protocol in emergency? La Radiologia Medica. 2016; 121: 711–718.

[31] Hughes WM, Natale C, Hellstrom WJG. The Management of Penile Fracture: a Review of the Literature with Special Consid-eration for Patients Undergoing Collagenase Clostridium His-tolyticum Injection Therapy. Current Urology Reports. 2021; 22: 13.

[32] Barros R, Ribeiro JGA, da Silva HAM, de Sá FR, Fosse AM Júnior, Favorito LA. Urethral injury in penile fracture: a narra-tive review. International Braz J Urol. 2020; 46: 152–157.

[33] Martínez Portillo FJ, Seif C, Braun PM, Spahn M, Alken P, Jüne-mann KP. Penile fractures: controversy of surgical vs. conserva-tive treatment. Aktuelle Urologie. 2003; 34: 33–36. (In German)

[34] Ahmadnia H, Younesi Rostami M, Kamalati A, Imani MM. Pe-nile fracture and its treatment: is retrograde urethrograghy nec-essary for management of penile fracture? Chinese Journal of Traumatology. 2014; 17: 338–340.

[35] Sokolakis I, Schubert T, Oelschlaeger M, Krebs M, Gschwend JE, Holzapfel K, et al. The Role of Magnetic Resonance Imaging in the Diagnosis of Penile Fracture in Real-Life Emergency Set-tings: Comparative Analysis with Intraoperative Findings. Jour-nal of Urology. 2019; 202: 552–557.

[36] Gamal WM, Osman MM, Hammady A, Aldahshoury MZ, Hus-sein MM, Saleem M. Penile Fracture: Long-Term Results of Surgical and Conservative Management. Journal of Trauma. 2011; 71: 491–493.

[37] Ghilan AM, Al-Asbahi WA, Ghafour MA, Alwan MA, Al-Khanbashi OM. Management of penile fractures. Saudi Medical Journal. 2008; 29: 1443–1447.

[38] Rodriguez D, Li K, Apoj M, Munarriz R. Epidemiology of Pe-nile Fractures in United States Emergency Departments: Access to Care Disparities may Lead to Suboptimal Outcomes. The Journal of Sexual Medicine. 2019; 16: 248–256.

[39] Ansari AA, Shamsodini A, Fadil E, Malik E, Yassin A. Penile Fracture: Treatment Outcomes of 26 Cases. Journal of Men’s Health. 2009; 3: 260.

[40] Kozacıoğlu Z, Ceylan Y, Aydoğdu Ö, Bolat D, Günlüsoy B, Minareci S. An update of Penile Fractures: Long-term signifi-cance of the number of hours elapsed till surgical repair on long-term outcomes. Turkish Journal of Urology. 2017; 43: 25–29.

[41] Bozzini G, Albersen M, Otero JR, Margreiter M, Cruz EG, Mueller A, et al. Delaying Surgical Treatment of Penile Frac-ture Results in Poor Functional Outcomes: Results from a Large Retrospective Multicenter European Study. European Urology Focus. 2018; 4: 106–110.

[42] Kozacioglu Z, Degirmenci T, Arslan M, Yuksel MB, Gunlusoy B, Minareci S. Long-Term Significance of the Number of Hours until Surgical Repair of Penile Fractures. Urologia Internation-alis. 2011; 87: 75–79.

[43] De Luca F, Garaffa G, Falcone M, Raheem A, Zacharakis E, Shabbir M, et al. Functional outcomes following immediate re-pair of penile fracture: a tertiary referral centre experience with 76 consecutive patients. Scandinavian Journal of Urology. 2017; 51: 170–175.

[44] Kamdar C, Mooppan UMM, Kim H, Gulmi FA. Penile fracture: preoperative evaluation and surgical technique for optimal pa-tient outcome. BJU International. 2008; 102: 1640–1644.

[45] Barros R, Silva M, Antonucci V, Schulze L, Koifman L, Favorito L. Primary urethral reconstruction results in penile fracture. The Annals of the Royal College of Surgeons of England. 2018; 100: 21–25.

[46] El-Taher AM, Aboul-Ella HA, Sayed MA, Gaafar AA. Manage-ment of Penile Fracture. The Journal of Trauma: Injury, Infec-tion, and Critical Care. 2004; 56: 1138–1140.

[47] EI-Bahnasawy M, Gomha M. Penile fractures: the successful outcome of immediate surgical intervention. International Jour-nal of Impotence Research. 2000; 12: 273–277.

[48] Sawh SL, O’Leary MP, Ferreira MD, Berry AM, Maharaj D. Fractured penis: a review. International Journal of Impotence Research. 2008; 20: 366–369.

[49] Kominsky H, Beebe S, Shah N, Jenkins LC. Surgical reconstruc-tion for penile fracture: a systematic review. International Jour-nal of Impotence Research. 2020; 32: 75–80.

[50] Raheem AA, El-Tatawy H, Eissa A, Elbahnasy AH, Elbendary M. Urinary and sexual functions after surgical treatment of penile fracture concomitant with complete urethral disruption. Archivio Italiano di Urologia, Andrologia. 2014; 86: 15–19.

[51] Tang Z, Yang L, Wei Q, Wang F, Liu LR, Tan P, et al. Manage-ment and outcomes of penile fracture: a retrospective analysis of 62 cases with long-term assessment. Asian Journal of Androl-ogy. 2018; 20: 412–413.

[52] Hatzichristodoulou G, Dorstewitz A, Gschwend JE, Herkom-mer K, Zantl N. Surgical Management of Penile Fracture and Long‐Term Outcome on Erectile Function and Voiding. The Journal of Sexual Medicine. 2013; 10: 1424–1430.

[53] Ortac M, Özgor F, Caglar U, Esmeray A, Savun M, Sarılar Ö. Older age and a large tunical tear may be predictors of increased erectile dysfunction rates following penile fracture surgery. In-ternational Journal of Impotence Research. 2020; 32: 226–231.

[54] Barros R, Schul A, Ornellas P, Koifman L, Favorito LA. Impact of Surgical Treatment of Penile Fracture on Sexual Function. Urology. 2019; 126: 128–133.

[55] Greear GM, Koprowski CJ, Hsieh T. Managing complications of collagenase Clostridium histolyticum (CCH) injection. World Journal of Urology. 2020; 38: 287–292.

[56] Yafi FA, Anaissie J, Zurawin J, Sikka SC, Hellstrom WJG. Results of SMSNA Survey Regarding Complications Following Intralesional Injection Therapy with Collagenase Clostrid-ium Histolyticum for Peyronie’s Disease. The Journal of Sexual Medicine. 2016; 13: 684–689.

[57] Beilan JA, Baumgarten AS, Bickell M, Parker J, Carrion RE. Suspected Penile Fracture after Xiaflex Injection and Use of a VED. Urology. 2016; 98: 4–7.

[58] Natale C, McLellan DM, Yousif A, Hellstrom WJG. Review of Intralesional Collagenase Clostridium Histolyticum Injection Therapy and Related Combination Therapies in the Treatment of Peyronie’s Disease (an Update). Sexual Medicine Reviews. 2021; 9: 340–349.

[59] Beilan JA, Wallen JJ, Baumgarten AS, Morgan KN, Parker JL, Carrion RE. Intralesional Injection of Collagenase Clostridium histolyticum may Increase the Risk of Late-Onset Penile Frac-ture. Sexual Medicine Reviews. 2018; 6: 272–278.

[60] Sharma KL, Bole R, Yang D, Alom M, Savage J, Ziegelmann M, et al. Conservative management of suspected fractures in men undergoing collagenase clostridium histolyticum for Peyronie’s Disease is not associated with worsening of erectile function. International Journal of Impotence Research. 2022; 34: 100–107.

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