A comprehensive mechanistic basis of prostate cancer advancement & its personalized implementation-bridging the gap: present state and future prospect
1Department of Biotechnology, Siksha Bhavana, Visva-Bharati, 731235 Santiniketan, India
2Department of Information Scientist, Maulana Abul Kalam Azad University of Technology, Haringhata, 741249 Simhat, India
3Computer Education Training Program, NICS Computer, 700032 Kolkata, India
4Department of Urology, S.V.S Marwari Hospital, 700014 Kolkata, India
5Department of Urology, AMRI Hospitals-Salt Lake, Salt Lake City, 700098 Kolkata, India
6Department of Oncology, S.V.S Marwari Hospital, 700014 Kolkata, India
7Department of Zoology, City College, 700009 Kolkata, India
8Department of Urology & Oncology, Rabindranath Tagore International Institute of Cardiac Sciences, 700099 Kolkata, India
9Department of Urology, Nil Ratan Sircar Medical College & Hospital, 700014 Kolkata, India
10Department of Pharmacology, Medical College, 700073 Kolkata, India
11Department of Radiotherapy, IPGMER and SSKM Hospital, 700020 Kolkata, India
12Department of Urology, North City Hospital, 700054 Kolkata, India
13Department of Radiotherapy, Medical College, 700073 Kolkata, India
14Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 700026 Kolkata, India
15Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, 700073 Kolkata, India
16Department of Information Technology, Jadavpur University, 700098 Kolkata, India
17Department of Pathology, Saroj Gupta Cancer Centre & Research Institute, 700063 Kolkata, India
18Department of Endocrinology, Medical College, 700073 Kolkata, India
19Department of Zoology, Vidyasagar College for Women, 700006 Kolkata, India
20Machine Intelligence Unit, Indian Statistical Institute, 700108 Kolkata, India
21Department of Pharmacology, IPGMER and SSKM Hospital, 700020 Kolkata, India
22Department of Zoology, Surendranath College, 700009 Kolkata, India
23Department of Computer Science, St. Xavier's College, 700016 Kolkata, India
24Department of Pharmaceutical Technology, Jadavpur University, 700032 Kolkata, India
Submitted: 07 January 2021 Accepted: 06 February 2021
Online publish date: 12 April 2021
Despite signiﬁcant achievements in prostate cancer mechanistic understanding and its targeted therapies, currently there exists several major challenges that mainly arises during the therapy of advanced prostate cancer. Present prostate cancer precision medicine strategy principally suffers from several practical concerns, particularly in point of therapeutic resistance, tumor heterogeneity, complex clinical & pathological behavior and an extensive genomic perturbation landscape.
Prostate Cancer Systems-Medicine Initiative is a global trans-disciplinary movement taken from corre-sponding scientiﬁc domains to critically determine the nature of this major existing challenges and its corresponding most possible solutions by systematically accumulating the present existing knowledge. Basically, it explains the importance of broad spectrum cancer hallmark based integrative approaches for development of combination therapy associated strategic measures for metastatic castration resistant prostate cancer. The major ﬁndings of this initiative can be summarized by identiﬁcation of 136 therapeutic resistance mediators, 103 prostate cancer driver oncogenes and 8 progression pathways along with 5 terrain factors which centrally drives the basic events in prostate cancer pathogenesis, its further metastatic propagation and ultimate therapeutic resistance. In addition, it also attempts to summarize the critical features and basic challenging aspects of current therapeutic options.
Precision medicine; Therapy resistance; Cancer hallmarks; Terrain factors; Castration resistant prostate cancer (CRPC); Bone metastasis; Androgen receptor (AR)
Dipamoy Datta,Md Aftabuddin,Raja Kundu,Mayank Baid,Sanjoy Kumar Das,Supriti Sarkar,Suresh Bajoria,Tapan Kumar Mandal,Pragnadyuti Mandal,Chandan Banerjee,B Shiva Shankar,Anish Banerjee,Chinmay Kumar Panda,Sougata Sarkar,Nilkantha Garain,Subrata Chakraborty,Anirban Sinha,Chaitali Banerjee,Losiana Nayak,Aniruddha Bagchi,Subhadra Roy,Kaushik Goswami,Leena Kumari. A comprehensive mechanistic basis of prostate cancer advancement & its personalized implementation-bridging the gap: present state and future prospect. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.029.
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