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Open Access Special Issue

Mechanisms of castration resistant prostate cancer formation and progression through neuroendocrine differentiation

  • Xueping Ma1
  • Xu Jiang1
  • Xuezhen Yang1

1Department of Urology, the Second Affiliated Hospital of Bengbu Medical College, 233020 Bengbu, Anhui, China

DOI: 10.31083/jomh.2021.040 Vol.17,Issue 4,September 2021 pp.17-21

Submitted: 02 March 2021 Accepted: 22 March 2021

Published: 30 September 2021

(This article belongs to the Special Issue Basic research of prostate cancer)

*Corresponding Author(s): Xuezhen Yang E-mail:


Normal prostate tissues consist mainly of epithelial cells, including secretory epithelial cells, basal cells, and neuroendocrine cells, and of mesenchymal cells, including smooth muscle cells and fibroblasts. The mechanisms leading to castration resistant prostate cancer (CRPC) are complex and diverse, but most involve neuroendocrine differentiation. In fact, during the development of prostate cancer, some of the tumor cells transform into neuroendocrine-like cells. This transition is a main underlying mechanism of CRPC formation.


Prostate cancer; Neuroendocrine differentiation; Castration resistance prostate cancer

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Xueping Ma,Xu Jiang,Xuezhen Yang. Mechanisms of castration resistant prostate cancer formation and progression through neuroendocrine differentiation. Journal of Men's Health. 2021. 17(4);17-21.


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