Article Data

  • Views 708
  • Dowloads 143

Original Research

Open Access

Sex-specific in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

  • Kyu Su Lee1
  • Jae Min Lee2
  • Chang Gi Kong3
  • Cho Hee Park4
  • Hyun Yoon5,*,

1Department of Radiological Science, Hanlyo University, 57764 Gwangyangsi, South Korea

2Department of Emergency Medical Technology, Gwangju Health University, 62287 Gwangsan-gu, South Korea

3Department of Radiology, Cheomdan Hospital, 62274 Gwangsan-gu, South Korea

4Department of global Medical Beauty, Konyang University, 32992 Nonsan-si, South Korea

5Department of Biomedical Laboratory Science, Wonkwang Health Science University, 54538 Iksan-si, South Korea

DOI: 10.31083/jomh.2021.064 Vol.18,Issue 1,January 2022 pp.1-8

Submitted: 12 March 2021 Accepted: 23 March 2021

Published: 31 January 2022

*Corresponding Author(s): Hyun Yoon E-mail: yh9074@yahoo.co.kr

Abstract

Background and objective: The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults.

Material and methods: Data from 5122 subjects (2251 men and 2871 women) in the seventh Korean National Health and Nutrition Examination Survey (KNHANES VII-2, 2017) were analyzed.

Results: Systolic blood pressure (SBP) and PP were significant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. In women, SBP, diastolic blood pressure (DBP), and PP were not significant factors determining the OR for hyperuricemia. After adjusting for related variables, the OR of hyperuricemia was significantly higher in the high PP group (PP >60.0 mmHg) for men (OR, 1.760; 95% confidence interval [CI], 1.152--2.688) and the overall population (OR, 1.557; 95% CI, 1.132--2.140) compared with the normal PP group, but this trend was not seen in women (OR, 1.060; 95% CI, 0.646--1.740).

Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women.

Keywords

Uric acid; Pulse pressure; Systolic blood pressure; Gender difference; Non-diabetic population

Cite and Share

Kyu Su Lee,Jae Min Lee,Chang Gi Kong,Cho Hee Park,Hyun Yoon. Sex-specific in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey. Journal of Men's Health. 2022. 18(1);1-8.

References

[1] Ioannou CV, Morel DR, Katsamouris AN, Katranitsa S, Startchik I, Kalangos A, et al. Left ventricular hypertrophy induced by reduced aortic compliance. Journal of Vascular Research. 2009; 46: 417–425.

[2] White WB. Systolic versus diastolic blood pressure versus pulse pressure. Current Cardiology Reports. 2002; 4: 463–467.

[3] McEvoy JW, Chen Y, Rawlings A, Hoogeveen RC, Ballantyne CM, Blumenthal RS, et al. Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events. Journal of the American College of Cardiology. 2016; 68: 1713–1722.

[4] Vidal-Petiot E, Ford I, Greenlaw N, Ferrari R, Fox KM, Tardif J, et al. Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study. Lancet. 2016; 388: 2142–2152.

[5] Mitchell GF, Vasan RS, Keyes MJ, Parise H, Wang TJ, Larson MG, et al. Pulse Pressure and Risk of New-Onset Atrial Fibrillation. Journal of the American Medical Association. 2007; 297: 709–715.

[6] Pääkkö TJW, Perkiömäki JS, Kesäniemi YA, Ylitalo AS, Lumme JA, Huikuri HV, et al. Increasing ambulatory pulse pressure predicts the development of left ventricular hypertrophy during long-term follow-up. Journal of Human Hypertension. 2018; 38: 180–189.

[7] Said MA, Eppinga RN, Lipsic E, Verweij N, van der Harst P. Relationship of Arterial Stiffness Index and Pulse Pressure with Cardiovascular Disease and Mortality. Journal of the American Heart Association. 2018; 7: e007621.

[8] George J, Struthers AD. Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vascular Health Risk Management. 2009; 5: 265–272.

[9] Lin KC, Lin HY, Chou P. Community based epidemiological study on hyperuricemia and gout in Kin-Hu, Kinmen. The Journal of Rheumatology. 2000; 27: 1045–1050.

[10] Feig DI, Kang D, Johnson RJ. Uric acid and cardiovascular risk. the New England Journal of Medicine. 2008; 359: 1811–1821.

[11] Liu W, Hung C, Chen S, Yeh S, Lin M, Chiu Y, et al. Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality. Clinical Journal of the American Society of Nephrology. 2012; 7: 541–548.

[12] Sánchez-Lozada LG, Soto V, Tapia E, Avila-Casado C, Sautin YY, Nakagawa T, et al. Role of oxidative stress in the renal abnormal-ities induced by experimental hyperuricemia. American Journal of Physiology-Renal Physiology. 2008; 295: F1134–F1141.

[13] Chen X, Li Y, Sheng C, Huang Q, Zheng Y, Wang J. Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting. American Journal of Hypertension. 2010; 23: 387–392.

[14] Choi HY, Kim S, Choi AR, Kim SG, Kim H, Lee JE, et al. Hyperuricemia and risk of increased arterial stiffness in healthy women based on health screening in Korean population. PLoS ONE. 2017; 12: e0180406.

[15] Ramirez-Sandoval JC, Sanchez-Lozada LG, Madero M. Uric Acid, Vascular Stiffness, and Chronic Kidney Disease: is there a Link? Blood Purification. 2017; 43: 189–195.

[16] McEvoy JW, Chen Y, Rawlings A, Hoogeveen RC, Ballantyne CM, Blumenthal RS, et al. Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events: Implications for Blood Pressure Control. Journal of the American College of Cardiology. 2016; 68: 1713–1722.

[17] Caliceti C, Calabria D, Roda A, Cicero AFG. Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: a Critical Review. Nutrients. 2017; 9: E395.

[18] Wu J, Qiu L, Cheng X, Xu T, Wu W, Zeng X, et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population. Scientific Reports. 2017; 7: 5456.

[19] Mehta T, Nuccio E, McFann K, Madero M, Sarnak MJ, Jalal D. Association of Uric Acid with Vascular Stiffness in the Framingham Heart Study. American Journal of Hypertension. 2015; 28: 877–883.

[20] Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, et al. Uric Acid is a Strong Risk Marker for Developing Hypertension from Prehypertension. Hypertension. 2018; 71: 78–86.

[21] Wakuda H, Uchida S, Ikeda M, Tabuchi M, Akahoshi Y, Shinozuka K, et al. Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice. Biological &Amp; Pharmaceutical Bulletin. 2014; 37: 1866–1871.

[22] Cuspidi C, Facchetti R, Bombelli M, Sala C, Tadic M, Grassi G, et al. Prevalence and correlates of new-onset left ventricular geometric abnormalities in a general population: the PAMELA study. Journal of Hypertension. 2016; 34: 1423–1431.

[23] Bavishi C, Messerli FH, Rimoldi SF. Serum Uric Acid in Primary Hypertension: from Innocent Bystander to Primum Movens? Hyper-tension. 2016; 67: 845–847.

[24] Mazzali M, Kanellis J, Han L, Feng L, Xia Y, Chen Q, et al. Hype-ruricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. American Journal of Physiology Renal Physiology. 2002; 282: F991–F997.

[25] Chen C, Hsu Y, Lee T. Impact of elevated uric acid on ventricular re-modeling in infarcted rats with experimental hyperuricemia. American Journal of Physiology Heart and Circulatory Physiology. 2011; 301: H1107–H1117.

[26] Kao MP, Ang DS, Gandy SJ, Nadir MA, Houston JG, Lang CC, et al. Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease. Journal of the American Society of Nephrology. 2011; 22: 1382–1389.

[27] Szwejkowski BR, Gandy SJ, Rekhraj S, Houston JG, Lang CC, Morris AD, et al. Allopurinol reduces left ventricular mass in patients with type 2 diabetes and left ventricular hypertrophy. Journal of the American College of Cardiology. 2013; 62: 2284–2293.

[28] Kurahashi H, Watanabe M, Sugimoto M, Ariyoshi Y, Mahmood S, Araki M, et al. Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. Endocrine Journal. 2013; 60: 1321–1327.

[29] Hak AE, Choi HK. Menopause, postmenopausal hormone use and serum uric acid levels in us women–the third National Health and Nutrition Examination Survey. Arthritis Research & Therapy. 2008; 10: R116.

[30] Jung JH, Song GG, Lee YH, Kim J, Hyun MH, Choi SJ. Serum uric acid levels and hormone therapy type: a retrospective cohort study of postmenopausal women. Menopause. 2018; 25: 77–81.

[31] Mumford SL, Dasharathy SS, Pollack AZ, Perkins NJ, Mattison DR, Cole SR, et al. Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study. Human Reproduction. 2013; 28: 1853–1862.

[32] Zangana SN. The impact of gender on serum uric acid levels in hypertensive patients with left ventricular hypertrophy in Erbil city-Iraq. International Journal of Medical Research and Health Sciences. 2016; 2: 4–8.

[33] Zheng X, Wei Q, Long J, Gong L, Chen H, Luo R, et al. Gender-specific association of serum uric acid levels and cardio-ankle vascular index in Chinese adults. Lipids in Health and Disease. 2018; 17: 80.

[34] Matsumura K, Ohtsubo T, Oniki H, Fujii K, Iida M. Gender-related association of serum uric acid and left ventricular hypertrophy in hypertension. Circulation Journal. 2006; 70: 885–888.

[35] Canepa M, Viazzi F, Strait JB, Ameri P, Pontremoli R, Brunelli C, et al. Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging. Hypertension. 2017; 69: 228–235.

[36] Kuo C, Yu K, Luo S, Ko Y, Wen M, Lin Y, et al. Role of uric acid in the link between arterial stiffness and cardiac hypertrophy: a cross-sectional study. Rheumatology. 2010; 49: 1189–1196.

[37] Kurata A, Shigematsu Y, Higaki J. Sex-related differences in relations of uric acid to left ventricular hypertrophy and remodeling in Japanese hypertensive patients. Hypertension Research. 2005; 28: 133–139.

[38] Baena CP, Lotufo PA, Mill JG, Cunha Rde S, Benseñor IJ. Serum Uric Acid and Pulse Wave Velocity Among Healthy Adults: Baseline Data From the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil). American Journal of Hypertension. 2015; 28: 966–970.

[39] Fairweather D, Petri MA, Coronado MJ, Cooper LT. Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis. Expert Review of Clinical Immunology. 2012; 8: 269–284.

[40] Fairweather D. Sex differences in inflammation during atherosclerosis. Clinical Medicine Insights. Cardiology. 2015; 8: S49–S59.

[41] Neogi T, Ellison RC, Hunt S, Terkeltaub R, Felson DT, Zhang Y. Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study. The Journal of Rheumatology. 2009; 36: 378–384.

[42] Pääkkö TJW, Perkiömäki JS, Kesäniemi YA, Ylitalo AS, Lumme JA, Huikuri HV, et al. Increasing ambulatory pulse pressure predicts the development of left ventricular hypertrophy during long-term follow-up. Journal of Human Hypertension. 2018; 32: 180–189.

[43] White WB. Systolic versus diastolic blood pressure versus pulse pressure. Current Cardiology Reports. 2002; 4: 463–467.

[44] Pérez-Lahiguera FJ, Rodilla E, Costa JA, Gonzalez C, Martín J, Pascual JM. Relationship of central and peripheral blood pressure to left ventricular mass in hypertensive patients. Revista Espanola De Cardiologia. 2012; 65: 1094–1100.

[45] Lin X, Wang X, Li X, Song L, Meng Z, Yang Q, et al. Gender-and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: a Cross-Sectional Study. International Journal of Endocrinology. 2019; 2019: 7545137.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Directory of Open Access Journals (DOAJ) DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.

SCImago The SCImago Journal & Country Rank is a publicly available portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database (Elsevier B.V.)

Publication Forum - JUFO (Federation of Finnish Learned Societies) Publication Forum is a classification of publication channels created by the Finnish scientific community to support the quality assessment of academic research.

Scopus CiteScore 0.7 (2021) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Norwegian Register for Scientific Journals, Series and Publishers Search for publication channels (journals, series and publishers) in the Norwegian Register for Scientific Journals, Series and Publishers to see if they are considered as scientific. (https://kanalregister.hkdir.no/publiseringskanaler/Forside).

Submission Turnaround Time

Conferences

Top