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Original Research

Open Access Special Issue

Inflammatory bowel disease is an independent risk factor for male erectile dysfunction

  • Sedat Tastemur1
  • Yusuf Kasap1
  • Samet Senel1
  • Bayram Yesil2

1Department of Urology, Ankara City Hospital, 06800 Ankara, Turkey

2Department of Gastroenterology, Ankara City Hospital, 06800 Ankara, Turkey

DOI: 10.31083/jomh.2021.095 Vol.18,Issue 2,February 2022 pp.1-5

Submitted: 14 May 2021 Accepted: 05 July 2021

Published: 28 February 2022

*Corresponding Author(s): Sedat Tastemur E-mail:


Background and objective: Inflammatory bowel diseases (IBD) are chronic diseases involving the gastrointestinal system, including ulcerative colitis (UC) and Crohn's disease (CD). Studies have shown a relationship between inflammatory bowel diseases and sexual dysfunction in men but it has been reported that this is due to surgery or the patient's psychological state. In our study, we aimed to assess the impact of IBD on the sexual functioning of male patients who has no previous pelvic surgery by evaluating the depression status of the patients.

Materials and methods: The 334 patients who were followed up in our gastroenterology outpatient clinic between January 2021 and March 2021 were included in the study and they were divided into 2 groups as with (n = 146) and without IBD (n = 188). None of the patients had a history of pelvic surgery or pelvic radiotherapy due to IBD or any other disease. The two groups were compared in terms of demographic data, comorbidities, sexual function, depression status and blood tests. International Index of Erectile Function (IIEF) was used in the evaluation of sexual functions, and the Beck Depression Inventory (BDI) was used in the evaluation of depression. Risk factors for erectile dysfunction (ED) were determined.

Results: The mean Beck depression test scores of the two groups were found to be similar (p = 0.361). ED was detected in 52.7% of patients with IBD and 32.4% of patients without IBD (p < 0.0001). In multivariate regression analysis, age (p = 0.008), smoking (p < 0.001), presence of diabetes mellitus (p = 0.02) and presence of IBD (p < 0.001) were determined as independent risk factors for ED. Conclusion: Inflammatory bowel diseases can cause ED regardless of the pelvic surgery performed and the psychological status that occur in these patients.


Erectile dysfunction; Depression; Inflammatory bowel diseases; Pelvic surgery

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Sedat Tastemur,Yusuf Kasap,Samet Senel,Bayram Yesil. Inflammatory bowel disease is an independent risk factor for male erectile dysfunction. Journal of Men's Health. 2022. 18(2);1-5.


[1] Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017; 390: 2769–2778.

[2] Iglesias-Rey M, Barreiro-de Acosta M, Caamaño-Isorna F, Rodríguez IV, Ferreiro R, Lindkvist B, et al. Psychological Factors are Associated with Changes in the Health-related Quality of Life in Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2014; 20: 92–102.

[3] Siegel CA, Allen JI, Melmed GY. Translating Improved Quality of Care into an Improved Quality of Life for Patients with Inflammatory Bowel Disease. Clinical Gastroenterology and Hepatology. 2013; 11: 908–912.

[4] Sanders JN, Gawron LM, Friedman S. Sexual satisfaction and inflammatory bowel diseases: an interdisciplinary clinical challenge. American Journal of Obstetrics and Gynecology. 2016; 215: 58–62.

[5] Allocca M, Gilardi D, Fiorino G, Furfaro F, Peyrin-Biroulet L, Danese S. Sexual and reproductive issues and inflammatory bowel disease. European Journal of Gastroenterology & Hepatology. 2018; 30: 316–322.

[6] Jedel S, Hood MM, Keshavarzian A. Getting Personal. Inflammatory Bowel Diseases. 2015; 21: 923–938.

[7] Leenhardt R, Rivière P, Papazian P, Nion-Larmurier I, Girard G, Laharie D, et al. Sexual health and fertility for individuals with inflammatory bowel disease. World Journal of Gastroenterology. 2019; 25: 5423–5433.

[8] Cappelleri JC, Siegel RL, Glasser DB, Osterloh IH, Rosen RC. Relationship between patient self-assessment of erectile dysfunction and the sexual health inventory for men. Clinical Therapeutics. 2001; 23: 1707–1719.

[9] Whisman MA, Richardson ED. Normative Data on the Beck Depres-sion Inventory - second Edition (BDI-II) in College Students. Journal of Clinical Psychology. 2015; 71: 898–907.

[10] Zippe C, Nandipati K, Agarwal A, Raina R. Sexual dysfunction after pelvic surgery. International Journal of Impotence Research. 2006; 18: 1–18.

[11] McK. Watts J, De Dombal FT, Goligher JC. Long-term complications and prognosis following major surgery for ulcerative colitis. British Journal of Surgery. 1966; 53: 1014–1023.

[12] Guyatt G, Mitchell A, Irvine EJ, Singer J, Williams N, Goodacre R, et al. A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology. 1989; 96: 804–810.

[13] Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng S, Savova G, et al. Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn’s Disease and Ulcerative Colitis. American Journal of Gastroenterology. 2013; 108: 594–601.

[14] Cho HS, Park JM, Lim CH, Cho YK, Lee IS, Kim SW, et al. Anxiety, Depression and Quality of Life in Patients with Irritable Bowel Syndrome. Gut and Liver. 2011; 5: 29–36.

[15] Bel LGJ, Vollebregt AM, Van der Meulen-de Jong AE, Fidder HH, Ten Hove WR, Vliet-Vlieland CW, et al. Sexual Dysfunctions in Men and Women with Inflammatory Bowel Disease. Journal of Sexual Medicine. 2015; 12: 1557–1567.

[16] Timmer A, Bauer A, Dignass A, Rogler G. Sexual Function in Persons with Inflammatory Bowel Disease: a Survey with Matched Controls. Clinical Gastroenterology and Hepatology. 2007; 5: 87–94.

[17] Shmidt E, Suárez-Fariñas M, Mallette M, Moniz H, Bright R, Shah SA, et al. Erectile Dysfunction is Highly Prevalent in Men with Newly Diagnosed Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2019; 25: 1408–1416.

[18] Hammami MB, Mahadevan U. Men with Inflammatory Bowel Disease: Sexual Function, Fertility, Medication Safety, and Prostate Cancer. American Journal of Gastroenterology. 2020; 115: 526–534.

[19] Ma S, Veysey M, Ersser S, Mason-Jones A, Galdas P. The impact of inflammatory bowel disease on sexual health in men: A scoping review. Journal of Clinical Nursing. 2020; 29: 3638–3651.

[20] Rodrigues F, Fais R, Tostes R, Carneiro F. There is a Link between Erectile Dysfunction and Heart Failure: it could be Inflammation. Current Drug Targets. 2015; 16: 442–450.

[21] Wilton KM, Achenbach SJ, Karmacharya P, Ernste FC, Matteson EL, Crowson CS. Erectile Dysfunction in Men with Psoriatic Arthritis: a Population-based Cohort Study. Journal of Rheumatology. 2021; 48: 527–532.

[22] Saygın H, Tosun M, Öztürk A, Ergin İe, Kıraç E, Aydemir Asdemir, et al. Effects of psoriasis and metabolic syndrome on male sexual functions. Journal of Men’s Health. 2021; 17: 91–95.

[23] Gonzalez-Gay MA, Gonzalez-Juanatey C, Martin J. Rheumatoid Arthritis: a Disease Associated with Accelerated Atherogenesis. Seminars in Arthritis and Rheumatism. 2005; 35: 8–17.

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