Fertility outcome of patients with CBAVD: a single-institution experience
1Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China
2Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China
3Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China
4Center for Genetics, National Research Institute for Family Planning, 100081 Beijing, China
DOI: 10.31083/jomh.2021.120 Vol.18,Issue 4,April 2022 pp.1-7
Submitted: 28 July 2021 Accepted: 09 September 2021
Published: 30 April 2022
Background and objective: Congenital bilateral absence of the vas deferens (CBAVD) is not common and fertility outcome is not clear. This study is to report fertility outcomes of infertile male with CBAVD.
Material and methods: Our study cohort comprised CBAVD males who were enrolled from 2005 to 2019. Baseline information was collected including mean age, previous medical history, duration of infertility, sex hormone assays, ejaculate volume/pH, parameters of sperm retrieved by percutaneous epididymal sperm aspiration (PESA), development of seminal vesicle TRUS, follow up fertility outcomes of the patients with Intracytoplasmic sperm injection (ICSI)and compared the impact of varies male factors on fertility outcomes.
Results: 172 participants with CBAVD were analyzed. A total of 211 ICSI cycles were performed and the live birth rate was 46.92%. Among 126 live births, 57 (45.24%) were boy and 69 (54.76%) were girl. The neonatal weight and height are 3036.83 ± 672.17 g, 49.43 ± 2.49 cm, respectively. There were no significant differences between successes group of couples and fail group of couples for first ICSI cycles cases in terms of age (P = 0.09), testicle volume (left P = 0.96, right P = 0.41), sex hormones (P > 0.05), ejaculate volume (P = 0.79), ejaculate pH (P = 0.78) or sperm quality parameters from PESA (P > 0.05). Conclusions: This study indicates that the clinical characteristics of male with CBAVD had no impact on fertility outcomes.
Male infertility; CBAVD; Fertility outcome; Percutaneous epididymal sperm aspiration; Intracytoplasmic sperm injection
Chengquan Ma,Zhengyi Sun,Jing Wang,Binbin Wang,Hongjun Li. Fertility outcome of patients with CBAVD: a single-institution experience. Journal of Men's Health. 2022. 18(4);1-7.
 Jequier AM, Ansell ID, Bullimore NJ. Congenital absence of the vasa deferentia presenting with infertility. Journal of Andrology. 1985; 6: 15–19.
 Hussein TM, Zakaria NH, Zahran AM. Clinical, laboratory and genetic assessment of patients with congenital bilateral absent vas deferens. Andrologia. 2011; 43: 16–22.
 Dumur V, Gervais R, Rigot JM, Delomel-Vinner E, Decaestecker B, Lafitte JJ, et al. Congenital bilateral absence of the vas deferens (CBAVD) and cystic fibrosis transmembrane regulator (CFTR): correlation between genotype and phenotype. Human Genetics. 1996; 97: 7–10.
 Fedder J, Jørgensen MW, Engvad B. Prevalence of CBAVD in azoospermic men carrying pathogenic CFTR mutations - Evaluated in a cohort of 639 non-vasectomized azoospermic men. Andrology. 2021; 9: 588–598.
 Lotti F, Maggi M. Ultrasound of the male genital tract in relation to male reproductive health. Human Reproduction Update. 2015; 21: 56–83.
 Dohle GR, Veeze HJ, Overbeek SE, van den Ouweland AMW, Halley DJJ, Weber RFA, et al. The complex relationships between cystic fibrosis and congenital bilateral absence of the vas deferens: clinical, electrophysiological and genetic data. Human Reproduction. 1999; 14: 371–374.
 Silber SJ, Nagy ZP, Liu J, Godoy H, Devroey P, Van Steirteghem AC. Conventional in-vitro fertilization versus intracytoplasmic sperm in-jection for patients requiring microsurgical sperm aspiration. Human Reproduction. 1994; 9: 1705–1709.
 Craft I, Bennett V, Nicholson N. Fertilising ability of testicular spermatozoa. Lancet. 1993; 342: 864.
 Ządzińska E, Rosset I, Mikulec A, Domański C, Pawłowski B. Impact of economic conditions on the secondary sex ratio in a post-communist economy. Homo. 2011; 62: 218–227.
 Hamamatsu Y, Inoue Y, Watanabe C, Umezaki M. Impact of the 2011 earthquake on marriages, births and the secondary sex ratio in Japan. Journal of Biosocial Science. 2014; 46: 830–841.
 Fareed M, Kaisar Ahmad M, Azeem Anwar M, Afzal M. Impact of consanguineous marriages and degrees of inbreeding on fertility, child mortality, secondary sex ratio, selection intensity, and genetic load: a cross-sectional study from Northern India. Pediatric Research. 2017; 81: 18–26.
 Bae J, Kim S, Barr DB, Buck Louis GM. Maternal and paternal serum concentrations of persistent organic pollutants and the secondary sex ratio: a population-based preconception cohort study. Environmental Research. 2018; 161: 9–16.
 Yorifuji T, Kashima S. Secondary sex ratio in regions severely exposed to methylmercury “Minamata disease”. International Archives of Occupational and Environmental Health. 2016; 89: 659–665.
 Matsuo K, Ushioda N, Udoff LC. Parental aging synergistically decreases offspring sex ratio. Journal of Obstetrics and Gynaecology Research. 2009; 35: 164–168.
 Bae J, Kim S, Chen Z, Eisenberg ML, Buck Louis GM. Human semen quality and the secondary sex ratio. Asian Journal of Andrology. 2017; 19: 374–381.
 Hubert D, Patrat C, Guibert J, Thiounn N, Bienvenu T, Viot G, et al. Results of assisted reproductive technique in men with cystic fibrosis. Human Reproduction. 2006; 21: 1232–1236.
 Ge B, Zhang M, Wang R, Wang D, Li T, Li H, et al. A rare frameshift variant in trans with the IVS9-5T allele of CFTR in a Chinese pedigree with congenital aplasia of vas deferens. Journal of Assisted Reproduction and Genetics. 2019; 36: 2541–2545.
 Li Z, Wang AY, Bowman M, Hammarberg K, Farquhar C, Johnson L, et al. ICSI does not increase the cumulative live birth rate in non-male factor infertility. Human Reproduction. 2018; 33: 1322–1330.
 Esteves SC. Percutaneous epididymal sperm aspiration as a method for sperm retrieval in men with obstructive azoospermia seeking fertility: operative and laboratory aspects. International Brazilian Journal of Urology. 2015; 41: 817–818.
 Moffat R, Beutler S, Schötzau A, De Geyter M, De Geyter C. Endometrial thickness influences neonatal birth weight in pregnancies with obstetric complications achieved after fresh IVF-ICSI cycles. Archives of Gynecology and Obstetrics. 2017; 296: 115–122.
 Fedder J, Gabrielsen A, Humaidan P, Erb K, Ernst E, Loft A. Malformation rate and sex ratio in 412 children conceived with epididymal or testicular sperm. Human Reproduction. 2007; 22: 1080–1085.
 Oates RD, Amos JA. The genetic basis of congenital bilateral absence of the vas deferens and cystic fibrosis. Journal of Andrology. 1994; 15: 1–8.
 Buffat C, Patrat C, Merlet F, Guibert J, Epelboin S, Thiounn N, et al. ICSI outcomes in obstructive azoospermia: influence of the origin of surgically retrieved spermatozoa and the cause of obstruction. Human Reproduction. 2006; 21: 1018–1024.
 Esteves SC, Roque M, Bedoschi G, Haahr T, Humaidan P. Intracy-toplasmic sperm injection for male infertility and consequences for offspring. Nature Reviews Urology. 2018; 15: 535–562.
 Wang H, An M, Liu Y, Hu K, Jin Y, Xu S, et al. Genetic diagnosis and sperm retrieval outcomes for Chinese patients with congenital bilateral absence of vas deferens. Andrology. 2020; 8: 1064–1069.
 He X, Cao Y, Zhang Z, Zhao J, Wei Z, Zhou P, et al. Spermatogenesis affects the outcome of ICSI for azoospermic patients rather than sperm retrieval method. Systems Biology in Reproductive Medicine. 2010; 56: 457–464.
 Veleva Z, Orava M, Nuojua-Huttunen S, Tapanainen JS, Martikainen H. Factors affecting the outcome of frozen-thawed embryo transfer. Human Reproduction. 2013; 28: 2425–2431.
 Reljič M, Knez J, Kovač V, Kovačič B. Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts. Journal of Assisted Reproduction and Genetics. 2017; 34: 775–779.
 Setti A, Halpern G, Braga D, Figueira R, Iaconelli A, Borges E. Association between parental anthropometric measures and the out-comes of intracytoplasmic sperm injection cycles. Journal of Assisted Reproduction and Genetics. 2019; 36: 461–471.
 Nicopoullos JDM, Gilling-Smith C, Almeida PA, Ramsay JWA. The results of 154 ICSI cycles using surgically retrieved sperm from azoospermic men. Human Reproduction. 2004; 19: 579–585.
 Akinsal EC, Baydilli N, Dogan ME, Ekmekcioglu O. Comorbidity of the congenital absence of the vas deferens. Andrologia. 2018. (in press)
 Yang B, Wang X, Zhang W, Li H, Wang B. Compound heterozygous mutations in CFTR causing CBAVD in Chinese pedigrees. Molecular Genetics & Genomic Medicine. 2018; 6: 1097–1103.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Directory of Open Access Journals (DOAJ) DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
SCImago The SCImago Journal & Country Rank is a publicly available portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database (Elsevier B.V.)
Publication Forum - JUFO (Federation of Finnish Learned Societies) Publication Forum is a classification of publication channels created by the Finnish scientific community to support the quality assessment of academic research.
Scopus: CiteScore 0.7 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Norwegian Register for Scientific Journals, Series and Publishers Search for publication channels (journals, series and publishers) in the Norwegian Register for Scientific Journals, Series and Publishers to see if they are considered as scientific. (https://kanalregister.hkdir.no/publiseringskanaler/Forside).