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Original Research

Open Access

Knockdown of B3GNT3 inhibits colon cancer cell growth and migration

  • Rehemu tula Aizimaiti1
  • Shayimu Paerhati1,*,

1Gastrointestinal Surgery (inpatient Area 1), Affiliated Cancer Hospital of Xinjiang Medical University, 830011 Urumqi, Xinjiang Uygur Autonomous Region, China

DOI: 10.22514/jomh.2024.095 Vol.20,Issue 6,June 2024 pp.85-91

Submitted: 26 March 2024 Accepted: 20 May 2024

Published: 30 June 2024

*Corresponding Author(s): Shayimu Paerhati E-mail: paerhati2727@163.com

Abstract

Colon cancer (CC) ranks among the most common malignant tumors globally. Providing theoretical support is essential to controlling CC and improving patients’ prognoses. Beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3), a protein-coding gene that encodes a member of the B3GNT family, affects multiple tumors. However, B3GNT3 remains largely unknown in terms of its role and mechanism in CC development and metastasis. This study explored B3GNT3’s effect on CC progression. We revealed that B3GNT3 is highly expressed in human CC tissues. B3GNT3 depletion suppressed CC cell growth. Knocking down B3GNT3 restrained CC cells’ motility. Mechanically, B3GNT3 knockdown blocks the nuclear factor kappa-B (NF-κB) pathway in CC cells. In summary, B3GNT3 depletion restrained CC cells’ growth and motility by targeting NF-κB pathway. As a potential target for CC, B3GNT3 appears promising.


Keywords

Colon cancer (CC); Beta-1,3-n-acetylglucosaminyltransferase 3 (B3GNT3); Growth; Motility; NF-κB pathway


Cite and Share

Rehemu tula Aizimaiti,Shayimu Paerhati. Knockdown of B3GNT3 inhibits colon cancer cell growth and migration. Journal of Men's Health. 2024. 20(6);85-91.

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