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Original Research

Open Access

ZNF677, a potential target in liver cancer, inhibits growth and stemness in hepatoma cells

  • Jun Wang1
  • Shi Wang1
  • Hailin Ye1
  • Xiaopeng Fan1,*,

1Department of Hepatobiliary Surgery, People Hospital of Lishui, 323000 Lishui, Zhejiang, China

DOI: 10.22514/jomh.2024.099 Vol.20,Issue 6,June 2024 pp.116-123

Submitted: 11 April 2024 Accepted: 29 May 2024

Published: 30 June 2024

*Corresponding Author(s): Xiaopeng Fan E-mail:


Liver cancer is a common type of cancer worldwide, with over 90% of cases being hepatocellular carcinoma (HCC). The discovery of new targets holds promise for improving the prognosis of HCC patients. Zinc finger protein 677 (ZNF677), a member of the Kruppel C2H type 2 zinc finger family, has been implicated in the progression of several tumors. However, its specific role in HCC remains unclear. In this study, we investigated the role of ZNF677 in HCC progression. Our analysis revealed low expression of ZNF677 in HCC, which correlated with patient prognosis. Functionally, ZNF677 suppressed the growth, migration, invasion, and stemness of HCC cells. Additional data confirmed its ability to block the stemness of HCC cells. Mechanistically, ZNF677 achieved these effects by targeting the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) axis. In summary, ZNF677 inhibits both growth and stemness in hepatoma cells via modulation of the PI3K/Akt axis.


Hepatocellular carcinoma (HCC); ZNF677; Prognosis; Stemness; Migration; Invasion; PI3K/Akt pathway

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Jun Wang,Shi Wang,Hailin Ye,Xiaopeng Fan. ZNF677, a potential target in liver cancer, inhibits growth and stemness in hepatoma cells. Journal of Men's Health. 2024. 20(6);116-123.


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