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Review

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Review of the androgen receptors and gastrointestinal cancer

  • Yeonhee Pyo1
  • Ki Han Kwon2,*,

1Department of Beauty Cosmetics, College of Biomedical and Health Science, Konkuk University, 27478 Chungju, Republic of Korea

2College of General Education, Kookmin University, 02707 Seoul, Republic of Korea

DOI: 10.22514/jomh.2024.144 Vol.20,Issue 9,September 2024 pp.17-24

Submitted: 28 January 2024 Accepted: 13 March 2024

Published: 30 September 2024

*Corresponding Author(s): Ki Han Kwon E-mail: kihan.kwon@kookmin.ac.kr

Abstract

Gastrointestinal (GI) cancer is the prevalent cause of global cancer deaths, and its effective treatments are lacking. This common malignancy can be identified through hematomas or black stools. It includes the cancers of digestive system, i.e., esophagus, stomach, liver, pancreas and colon. It is surgically removed followed by the conservative management. The incidence of GI cancer in men is 2–3 times higher compared to women. This higher prevalence in men is because of the involvement of sex steroid hormones via androgen receptor. The clinical case studies in men are continuously being conducted, however there are unanswered questions regarding the therapeutics. In this review, future therapeutic strategies of GI cancer and gastrointestinal stromal tumor (GIST) are being encompassed.


Keywords

Gastrointestinal cancer; Gastrointestinal stromal tumor; Sex steroid hormone; Men’s health


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Yeonhee Pyo,Ki Han Kwon. Review of the androgen receptors and gastrointestinal cancer. Journal of Men's Health. 2024. 20(9);17-24.

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