The influence of intermittent apnea on aortic hemodynamics in healthy young men
1Research Institute for Industrial Technology Aichi Institute of Technology, Toyota, 470-0392 Aichi, Japan
2Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
3Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
4Department of Biomedical Engineering, Toyo University, Kawagoe-Shi, 350-8585 Saitama, Japan
5Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology (AIST), 305-8566 Ibaraki, Japan
DOI: 10.31083/j.jomh1803076 Vol.18,Issue 3,March 2022 pp.1-7
Submitted: 01 September 2021 Accepted: 19 November 2021
Published: 31 March 2022
Background: Sleep apnea is known as a high-risk factor for cardiovascular disease (CVD); However, the influence of apnea on aor-tic blood pressure and augmentation index (AIx), which cardiac load and independent risks for a future CVD event, remains unclear. Therefore, this study aimed to examine the influence of intermittent normoxic apnea on aortic arterial hemodynamics in healthy men. Methods: Sixteen healthy young men (23 ± 1.6 years mean ± SD) underwent the repetitive 20-s apnea with a 40 s interval for 20 min. During the interval, each subject maintained a breath pace at 15 breaths/min. Central hemodynamics were evaluated every 5 min by pulse wave analysis from peripheral (radial) arterial pressure waveforms via general transfer function method and compared among three phases defined as “breath” (for 20 s before apnea), “apnea”, and “rebreathe” (for 20 s after apnea). The baseline values were calculated from the first breathing cycle and compared with each breathing phase every 5 min. Results: Aortic systolic blood pressure and AIx were significantly higher at rebreathe phase than the other phases. Likewise, heart rate and double product (aortic systolic blood pressure × heart rate) were significantly higher in rebreathe phase than the other phases. Conclusions: These results suggest that cardiac load is increased by intermittent normoxic apnea, especially during the rebreathing phase.
Intermittent apnea; Aortic pressure; Augmentation index
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