Evaluation of sex hormone proﬁles and seminal ﬂuid analysis in psoriatic patients and their correlation with psoriasis severity
1Department of General Surgery and Specialized Surgery, Faculty of Medicine, Yarmouk University, 21163 Irbid , Jordan
2Department of Clinical Sciences, Faculty of Medicine, Yarmouk University, 21163 Irbid , Jordan
3Department of Clinical Dermatology, Jordanian Royal medical services, 11855 Amman, Jordan
4Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, 71111 Maan, Jordan
DOI: 10.31083/jomh.2021.075 Vol.18,Issue 2,February 2022 pp.1-5
Submitted: 13 May 2021 Accepted: 24 June 2021
Published: 28 February 2022
Background and objective: Psoriasis is a chronic inﬂammatory skin condition characterized by thick silvery plaques, commonly involving the elbow, knees, lower back, and scalp. Psoriasis also affects the reproductive systems of patients. Males with untreated psoriasis are at risk of impaired fertility due to chronic systemic inﬂammation, which might affect the hormonal proﬁle and sexual accessory glands. In females, having psoriasis does not affect the chances of getting pregnant. This study aims to assess the effect of psoriasis, as a chronic inﬂammatory condition, on sex hormone proﬁles and seminal ﬂuid parameters.
Methods: 87 male patients aged 18−50 with psoriasis who fulﬁlled the inclusion criteria were included in the study and matched with healthy controls. Demographic and clinical data, including age, severity, duration, and body mass index (BMI) were recorded. All patients underwent a complete physical exam, including a skin and andrological exam, in addition to ultrasound scrotum and seminal ﬂuid analysis. Blood sample tests were conducted for a complete hormonal proﬁle, including luteinizing hormone (LH), follicular stimulating hormone (FSH), testosterone, and estradiol.
Results: The mean age of the case group was 39.5 ± 5.6 years, and the mean BMI was 24.0 ± 2.2. The mean duration of psoriasis was 6.5 ± 3.5 years. The mean levels of testosterone and LH of cases were lower than those of controls, whereas FSH and estradiol were abnormally higher among case groups. Sperm concentration, normal sperm motility, and normal sperm morphology were also found to be lower than in the case group. Age, psoriasis area, and severity index (PASI) scores were signiﬁcant predictors of sperm concentration (P = 0.000). The BMI was negatively correlated with sperm concentration (−0.249, P = 0.01), motility (−0.198, P = 0.05), and morphology (−0.205, P = 0.05). A negative correlation was found between the PASI score and sperm concentration (−0.519, P = 0.01).
Conclusion: The evaluation of seminal ﬂuid analysis and hormone proﬁles among psoriasis patients showed marked variability. However, it was evident that the levels of sex hormones and seminal parameters were lower among patients with psoriasis than the healthy controls; this may indicate the possibility of developing sexual dysfunction and infertility among patients with untreated psoriasis. The level of estradiol was found to be abnormally high among psoriasis cases, which may account for a possible compensatory mechanism in ongoing sexual dysfunction among psoriasis patients.
Psoriasis; Semen analysis; Sexual functions; Sex hormones
Mohammad Al-Zubi,Khaled Seetan,Bashar Jarrar,Asem Aldebei,Yousef Rubbai,Salah Daradkeh. Evaluation of sex hormone proﬁles and seminal ﬂuid analysis in psoriatic patients and their correlation with psoriasis severity. Journal of Men's Health. 2022. 18(2);1-5.
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