Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Effects of aerobic exercise training on circulating angiopoietin-like protein 2 in overweight and obese men: a pilot study
1Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, Japan
2Graduates School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, Japan
3Humanome Lab., Inc., Chuo-ku, 104-0045 Tokyo, Japan
4Institute of Sports and Arts Convergence (ISAC), Inha University, 22212 Incheon, Republic of Korea
5Faculty of Human Sciences, Shimane University, 690-8504 Shimane, Japan
6Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, 305-8575 Tsukuba, Japan
7Faculty of Sport Sciences, Waseda University, 359-1192 Saitama, Japan
DOI: 10.31083/jomh.2021.121 Vol.18,Issue 3,March 2022 pp.1-7
Submitted: 22 July 2021 Accepted: 02 September 2021
Published: 31 March 2022
*Corresponding Author(s): Seiji Maeda E-mail: maeda.seiji.gn@u.tsukuba.ac.jp
Background and objective: Angiopoietin-like protein 2 (ANGPTL2) is a pro-inflammatory adipokine that is upregulated in obesity and plays a role in the progression of cardiometabolic diseases, including diabetes and atherosclerosis. Aerobic exercise is one of the effective strategies for reducing the levels of various pro-inflammatory biomolecules in obese individuals. However, the effects of aerobic exercise training on circulating ANGPTL2 levels in obese individuals remain unclear. The objective of this study was to investigate the effect of aerobic exercise training on serum ANGPTL2 levels in overweight and obese men.
Material and methods: Twenty overweight and obese men (age, 49 ± 10 years; body mass index, 27.4± 2.2 kg/m2) completed a 12-week aerobic exercise training program (60–85% Heart ratemax, 40–60 min/day, 3 days/week). Before and after the exercise program, serum ANGPTL2 levels were measured using the enzyme-linked immunosorbent assay. Daily step counts and the different physical activities based on the intensity were assessed using a triaxial accelerometer.
Results: Serum ANGPTL2 levels were significantly decreased after the 12-week aerobic exercise training program ((3.0 ± 0.6) vs. (2.7 ± 0.7) ng/mL, P < 0.05). Daily step counts ((8362 ± 4551) vs.(10357 ± 3168) steps/day, P < 0.05) and moderate- to vigorous-intensity physical activity (MVPA) time ((58 ± 45) vs. (76 ± 37) min/day, P < 0.001) were significantly increased after the exercise intervention. The changes in serum ANGPTL2 levels were negatively correlated with corresponding changes in daily step counts (partial r = –0.49, P < 0.05) and MVPA time (partial r = –0.47, P < 0.05) after adjustment for age and accelerometer wear time.
Conlcusion: These findings collectively suggest that aerobic exercise training, in particular an increase in MVPA, can be associated with decreased circulating levels of ANGPTL2 in overweight and obese men.
Angiopoietin-like protein 2; Inflammation, Aerobic exercise; Obesity
Jiyeon Park,Keisei Kosaki,Kanae Myoenzono,Youngju Choi,Takehiko Tsujimoto,Nobutake Shimojo,Seiji Maeda. Effects of aerobic exercise training on circulating angiopoietin-like protein 2 in overweight and obese men: a pilot study. Journal of Men's Health. 2022. 18(3);1-7.
[1] Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. Journal of Clinical Investigation. 2011; 121: 2111–2117.
[2] Pi-Sunyer X. The medical risks of obesity. Postgraduate Medicine. 2010; 121: 21–33.
[3] Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology. 2011; 11: 85–97.
[4] Kim I, Moon S, Koh KN, Kim H, Uhm C, Kwak HJ, et al. Molecular cloning, expression, and characterization of angiopoietin-related protein. Journal of Biological Chemistry. 1999; 274: 26523–26528.
[5] Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, et al. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metabolism. 2009; 10: 178–188.
[6] Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, et al. Serum angiopoietin–like protein 2 is a novel risk factor for cardio-vascular disease in the community. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36: 1686–1691.
[7] Muramoto A, Tsushita K, Kato A, Ozaki N, Tabata M, Endo M, et al. Angiopoietin-like protein 2 sensitively responds to weight reduction induced by lifestyle intervention on overweight Japanese men. Nutrition & Diabetes. 2012; 1: e20.
[8] Piché M, Thorin-Trescases N, Auclair A, Marceau S, Martin J, Fortier A, et al. Bariatric surgery-induced lower angiopoietin-like 2 protein is associated with improved cardiometabolic profile. The Canadian Journal of Cardiology. 2017; 33: 1044–1051.
[9] Oike Y, Kadomatsu T, Endo M. The role of ANGPTL2-induced chronic inflammation in lifestyle diseases and cancer. Inflammation and Regeneration. 2015; 35: 193–202.
[10] Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, et al. Angiopoietin-like protein 2 is associated with chronic kidney disease in a general japanese population. Circulation Journal. 2013; 77: 2311–2317.
[11] Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity Research. 2004; 11: 1048–1054.
[12] Kumagai H, Zempo-Miyaki A, Yoshikawa T, Eto M, So R, Tsujimoto T, et al. Which cytokine is the most related to weight loss-induced decrease in arterial stiffness in overweight and obese men? Endocrine Journal. 2018; 65: 53–61.
[13] You T, Arsenis NC, Disanzo BL, LaMonte MJ. Effects of exercise training on chronic inflammation in obesity. Sports Medicine. 2013; 43: 243–256.
[14] Park J, Choi Y, Mizushima R, Yoshikawa T, Myoenzono K, Tagawa K, et al. Dietary modification reduces serum angiopoietin-like protein 2 levels and arterial stiffness in overweight and obese men. Journal of Exercise Nutrition & Biochemistry. 2020; 23: 39–44.
[15] Larouche J, Yu C, Luo X, Farhat N, Guiraud T, Lalongé J, et al. Acute high-intensity intermittent aerobic exercise reduces plasma angiopoietin-like 2 in patients with coronary artery disease. The Canadian Journal of Cardiology. 2016; 31: 1232–1239.
[16] Miyaki A, Maeda S, Yoshizawa M, Misono M, Saito Y, Sasai H, et al. Effect of habitual aerobic exercise on body weight and arterial function in overweight and obese men. The American Journal of Cardiology. 2009; 104: 823–828.
[17] Maeda S, Miyaki A, Kumagai H, Eto M, So R, Tanaka K, et al. Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men. Coronary Artery Disease. 2014; 24: 583–588.
[18] Kumagai H, Zempo-Miyaki A, Yoshikawa T, Tsujimoto T, Tanaka K, Maeda S. Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increase in testosterone. Journal of Clinical Biochemistry and Nutrition. 2016; 58: 84–89.
[19] Kumagai H, Yoshikawa T, Zempo-Miyaki A, Myoenzono K, Tsuji-moto T, Tanaka K, et al. Vigorous physical activity is associated with regular aerobic exercise-induced increased serum testosterone levels in overweight/obese men. Hormone and Metabolic Research. 2018; 50: 73–79.
[20] Shiga T, Hamaguchi T, Oshima Y, Kanai H, Hirata M, Hosoda K, et al. ‘A new simple measurement system of visceral fat accumulation by bioelectrical impedance analysis,’ World Congress on Medical Physics and Biomedical Engineering. Munich, Germany. 2009.
[21] Ohkawara K, Oshima Y, Hikihara Y, Ishikawa-Takata K, Tabata I, Tanaka S. Rea1-time estimation of daily physical activity intensity by a triaxial accelerometer and a gravity-removal classification algorithm. British Journal of Nutrition. 2011; 105: 1681–1691.
[22] Tanaka C, Fujiwara Y, Sakurai R, Fukaya T, Yasunaga M, Tanaka S. Locomotive and non-locomotive activities evaluated with a triaxial accelerometer in adults and elderly individuals. Aging Clinical and Experimental Research. 2014; 25: 637–643.
[23] Sone H, Yoshimura Y, Tanaka S, Iimuro S, Ohashi Y, Ito H, et al. Cross-sectional association between BMI, glycemic control and energy intake in Japanese patients with type 2 diabetes. Diabetes Research and Clinical Practice. 2007; 77: S23–S29.
[24] Takahashi K, Yoshimura Y, Kaimoto T, Kunii D, Komatsu T, Yamamoto S. Validation of a food frequency questionnaire based on food groups for estimating individual nutrient intake. The Japanese Journal of Nutrition and Dietetics. 2001; 59: 221–232.
[25] Thorin-Trescases N, Hayami D, Yu C, Luo X, Nguyen A, Larouche J, et al. Exercise lowers plasma angiopoietin-like 2 in men with post-acute coronary syndrome. PLoS ONE. 2017; 11: e0164598.
[26] Koh Y, Park K. Responses of inflammatory cytokines following mod-erate intensity walking exercise in overweight or obese individuals. Journal of Exercise Rehabilitation. 2019; 13: 472–476.
[27] Vella Ca, Allison Ma, Cushman M, Jenny Ns, Miles Mp, Larsen B, et al. Physical activity and adiposity-related inflammation. Medicine & Science in Sports & Exercise. 2017; 49: 915–921.
[28] Zheng J, Zou J, Wang W, Feng X, Shi Y, Zhao Y, et al. Tumor necrosis factor-α increases angiopoietin-like protein 2 gene expression by activating Foxo1 in 3T3-L1 adipocytes. Molecular and Cellular Endocrinology. 2011; 339: 120–129.
[29] Meng Q, Wen L, Chen X, Zhong H. Association of serum angiopoietin-like protein 2 and epinephrine levels in metabolically healthy but obese individuals: in vitro and in vivo evidence. Experimen-tal and Therapeutic Medicine. 2019; 5: 1631–1636.
[30] Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. Journal of Applied Physiology. 2005; 98: 1154–1162.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Directory of Open Access Journals (DOAJ) DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
SCImago The SCImago Journal & Country Rank is a publicly available portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database (Elsevier B.V.)
Publication Forum - JUFO (Federation of Finnish Learned Societies) Publication Forum is a classification of publication channels created by the Finnish scientific community to support the quality assessment of academic research.
Scopus: CiteScore 0.9 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Norwegian Register for Scientific Journals, Series and Publishers Search for publication channels (journals, series and publishers) in the Norwegian Register for Scientific Journals, Series and Publishers to see if they are considered as scientific. (https://kanalregister.hkdir.no/publiseringskanaler/Forside).
Top