Special Issue Title:

COVID-19 and sex differences: is the men at risk?

Deadline for manuscript submissions: 30 June 2022

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Special Issue Editor

  • Guest Editor

    Tiziana CiarambinoE-MailWebsite

    Internal Medicine Department, Hospital of Marcianise, ASL Caserta, Italy

    Interests: Gender Medicine; Aging; Chronic Kidney Disease; Emergency Medicine; Internal Medicine; Public Health

Special Issue Information

Dear Colleagues,

Study about gender distribution, suggested that males account for 60% of COVID-19 patients. Reasons are not well explored yet. Some studies showed that even MERS-CoV and SARS-CoV infected more males than females. Pre-existing diseases, such as cardiovascular or respiratory impairment, hypertension or diabetes may unfavorably impact the course of the COVID-19. However, higher risk behaviors, such as alcohol abuse and smoking, more common in male than female, may play a role in the pathophysiological process of COVID-19. However, it has been reported that hormones such as sex-specific steroids (estrogens, androgens and progesterone), and activity of X-linked genes, exert different effects on immune regulation. In fact, these modulate the innate and adaptive immune response to virus infection and influence the immune response. It is well known that estrogen suppresses T and B cell lymphopoiesis, activates B cell function and influences T cell development. Moreover, estrogen regulates a number of cytokines (such as IL-1, IL10, and IFN-beta) that modulate the immune response. Progesterone increased IL-4, reduced IFN-beta (Th17) responses and reduced T cell proliferation and T cell dependent antibody responses. However, in CD8 T cells, progesterone reduced IFN-beta and cytotoxicity. Other possible explanation about these differences between male and female subjects could be related to a higher number and activity of innate immune cells in women. In particular, females are mosaics for X-linked genes, and this contribute to generate a stronger immune response (both innate and adaptive) and more frequent autoimmune and inflammatory diseases in female subjects. However, ACE-2 represents the primary route of infection of COVID-19 and it is located on X chromosome. Actions exerted by this enzyme consist not only in the conversion of Angiotensin I, but also in immunomodulation and prevention of lung injury, with a protective effect in female subjects.

Dr. Tiziana Ciarambino

Guest Editor


Men; Sex and Gender Differences; SARS-COV2; COVID-19; Outcome

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. JOMH is an international peer-reviewed open access journal published by MRE Press. As of January 2021, JOMH will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Published Papers (3 papers)

Open Access Special Issue

Effects of the COVID-19 Pandemic on Prostate Cancer Screening and Diagnosis

Ender Siyez

DOI: 10.31083/j.jomh1808167

(This article belongs to the Special Issue COVID-19 and sex differences: is the men at risk?)

Abstract ( 252 ) PDF (552.37 kB) ( 110 )

Open Access Special Issue

Factors Associated with Injuries and Gender Differences in Japanese Adolescent Athletes Returning to Sports Following the COVID-19 Restriction

Tsubasa Tashiro,Noriaki Maeda,Yuta Suzuki,Shogo Tsutsumi,Kazuki Fukui,Rami Mizuta,Honoka Ishihara,Makoto Komiya,Yukio Urabe

DOI: 10.31083/j.jomh1808175

(This article belongs to the Special Issue COVID-19 and sex differences: is the men at risk?)

Abstract ( 226 ) PDF (272.13 kB) ( 122 )

Open Access Special Issue

SARS-CoV-2 Spike Protein Influences Expression of ICOSL and ICAM-2 in Prostate Cancer

McKay Echols,Zuliang Deng,Coby Powers,Huaping Xiao,Ziwen Zhu,Marco Lequio,Samuel Leung,Qian Bai,Mark R. Wakefield,Yujiang Fang

DOI: 10.31083/j.jomh1810201

(This article belongs to the Special Issue COVID-19 and sex differences: is the men at risk?)

Abstract ( 237 ) PDF (1.69 MB) ( 133 )

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